{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:14Z","timestamp":1785451274331,"version":"3.56.0"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: This study aims to evaluate the relationship between spexin levels and nonalcoholic fatty liver disease in patients with polycystic ovary syndrome.  METHODS: The study included 90 participants, comprising 44 patients diagnosed with polycystic ovary syndrome and 46 age- and body mass index-matched controls. Participants\u2019 spexin, glucose, urea, alanine aminotransferase, aspartate aminotransferase, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, progesterone, follicle-stimulating hormone, luteinizing hormone, estradiol, total testosterone, free testosterone, and dehydroepiandrosterone sulfate levels were measured. The liver steatosis grading was done using the ultrasound-guided attenuation parameter from General Electric Healthcare. The parameters were evaluated between the groups.  RESULTS: Spexin levels in polycystic ovary syndrome patients were significantly lower compared to the control group (p&lt;0.001). Glucose, triglycerides, luteinizing hormone, total testosterone, free testosterone, and dehydroepiandrosterone sulfate levels were found to be significantly higher in polycystic ovary syndrome patients compared to the control group (p&lt;0.001). High-density lipoprotein levels in polycystic ovary syndrome patients were significantly lower compared to the control group (p&lt;0.001). The prevalence of liver steatosis was notably higher among the polycystic ovary syndrome patients compared to the control group (p&lt;0.001). In patients with polycystic ovary syndrome, spexin levels demonstrated significant negative correlations with body mass index, glucose, triglycerides, luteinizing hormone, total testosterone, free testosterone, and dehydroepiandrosterone sulfate (all p&lt;0.001). A strong negative correlation was observed between spexin levels and liver steatosis grading (p&lt;0.001).  CONCLUSION: Spexin is a coordinator in the metabolic relationship between polycystic ovary syndrome and liver health, suggesting its utility as a biomarker for detecting liver steatosis and related metabolic disturbances in this population.<\/jats:p>","DOI":"10.1590\/1806-9282.20241313","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:32:56Z","timestamp":1743582776000},"source":"Crossref","is-referenced-by-count":6,"title":["The relationship between spexin and liver steatosis in polycystic ovary syndrome: a novel analysis using ultrasound-guided attenuation parameter"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-9265","authenticated-orcid":false,"given":"\u0130zzet","family":"\u00d6zg\u00fcrl\u00fck","sequence":"first","affiliation":[{"name":"Etlik City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-0029","authenticated-orcid":false,"given":"Rasime Pelin","family":"Kavak","sequence":"additional","affiliation":[{"name":"Etlik City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2522-5719","authenticated-orcid":false,"given":"Berna","family":"Turhan","sequence":"additional","affiliation":[{"name":"Etlik City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-1202","authenticated-orcid":false,"given":"S\u00fcmeyya Duran","family":"Kaymak","sequence":"additional","affiliation":[{"name":"Etlik City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-2741","authenticated-orcid":false,"given":"Rabia","family":"\u015eeker","sequence":"additional","affiliation":[{"name":"Etlik City 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Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025000200614&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:33:32Z","timestamp":1743582812000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025000200614&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025000200614"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20241313","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20241313"}}