{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:16:22Z","timestamp":1782782182744,"version":"3.54.5"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Systemic lupus erythematosus is a chronic autoimmune disease with significant cardiac manifestations, including right ventricular dysfunction and pulmonary hypertension. This study aims to explore the relationship between endothelial PAS domain-containing protein 1 and ghrelin levels with right ventricular function in patients with systemic lupus erythematosus and assess their potential as biomarkers for cardiac involvement.  METHODS: A prospective study was conducted involving 34 patients with systemic lupus erythematosus and 35 healthy controls. Echocardiographic parameters were recorded. Serum levels of endothelial PAS domain-containing protein 1 and ghrelin were measured using enzyme-linked immunosorbent assay. Statistical analyses included comparisons between groups and correlations between biomarkers and echocardiographic parameters.  RESULTS: Patients with systemic lupus erythematosus had significantly higher levels of endothelial PAS domain-containing protein 1 and ghrelin compared with healthy controls (p&lt;0.001). Endothelial PAS domain-containing protein 1 showed a moderate positive correlation with right ventricular systolic motion (p=0.007). Patients with systemic lupus erythematosus and a higher disease activity had elevated endothelial PAS domain-containing protein 1 levels, particularly those with positive antiphospholipid antibodies (p&lt;0.001). No significant correlation was found between ghrelin levels and right ventricular function. Receiver operating characteristic curve analysis identified cutoff values for endothelial PAS domain-containing protein 1 (\u22651.871) and ghrelin (\u2265360.50) with moderate sensitivity and specificity for predicting systemic lupus erythematosus.  CONCLUSION: This study suggests that endothelial PAS domain-containing protein 1 and ghrelin may play important roles in the pathophysiology of right ventricular dysfunction in systemic lupus erythematosus.<\/jats:p>","DOI":"10.1590\/1806-9282.20241412","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:24:32Z","timestamp":1743582272000},"source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the cardiac impacts of endothelial PAS domain-containing protein 1 and ghrelin in patients with systemic lupus erythematosus"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-2180","authenticated-orcid":false,"given":"Yakup","family":"Alsancak","sequence":"first","affiliation":[{"name":"Necmettin Erbakan University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2928-1059","authenticated-orcid":false,"given":"Ahmet Taha","family":"Sahin","sequence":"additional","affiliation":[{"name":"Beyhekim Training and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-352X","authenticated-orcid":false,"given":"Oznur","family":"Keskin","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-3490","authenticated-orcid":false,"given":"Selman","family":"Parlak","sequence":"additional","affiliation":[{"name":"Beyhekim Training and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/joim.13557","article-title":"Systemic lupus erythematosus and cardiovascular disease","volume":"293","author":"Frosteg\u00e5rd 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