{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:08:50Z","timestamp":1776323330335,"version":"3.50.1"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this retrospective study was to evaluate the effects of cardioplegic solutions on myocardial protection factors in patients undergoing cardiac surgery with cardiopulmonary bypass and to evaluate the relationship between these effects and early clinical outcomes.  METHODS: A total of 78 patients were included in the study. The data of patients who received del Nido cardioplegia (Group 1; n=39) and blood cardioplegia (Group 2; n=39) during the operation were grouped and compared. Preoperative and postoperative routine parameters such as creatine phosphokinase, troponin I, C-reactive protein, and demographic data were recorded, and statistical analyses were performed.  RESULTS: Perfusion time, cross-clamp time, act pump, preoperative C-reactive protein, preoperative creatine phosphokinase, preoperative troponin I, postoperative C-reactive protein, postoperative creatine phosphokinase, postoperative troponin I values were significantly different between del Nido and blood groups (p&lt;0.05).  CONCLUSION: Del Nido cardioplegia provided myocardial protection and early postoperative favorable results compared to blood cardioplegia, which may make it a viable option for conventional cardiopulmonary bypass.<\/jats:p>","DOI":"10.1590\/1806-9282.20241451","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:09:46Z","timestamp":1746184186000},"source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the effect of cardioplegic solutions used in cardiac surgery on myocardial protection"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-1907","authenticated-orcid":false,"given":"Mahmut","family":"Padak","sequence":"first","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-7830","authenticated-orcid":false,"given":"Re\u015fat","family":"Dikme","sequence":"additional","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-4958","authenticated-orcid":false,"given":"Ezhar","family":"Ers\u00f6z","sequence":"additional","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-8149","authenticated-orcid":false,"given":"Yasemin","family":"Hacanl\u0131","sequence":"additional","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst T","year":"2013","journal-title":"Circ Res"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.recesp.2020.07.020","article-title":"Coexistence of transmural and lateral wavefront progression of myocardial infarction in the human heart","volume":"74","author":"Lorca R","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1590\/1806-9282.20210642","article-title":"Effect of del Nido cardioplegia use on kidney injury after coronary bypass operations","volume":"67","author":"Ka\u011fan As A","year":"2021","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S367","DOI":"10.21037\/jtd.2018.12.65","article-title":"The del Nido cardioplegia in adult cardiac surgery: reinventing myocardial protection?","volume":"11","author":"Luo W","year":"2019","journal-title":"J Thorac Dis"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1479.e5","DOI":"10.1016\/j.jtcvs.2019.09.027","article-title":"Del Nido cardioplegia in isolated adult coronary artery bypass surgery","volume":"160","author":"Timek TA","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/0267659111424788","article-title":"Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures","volume":"27","author":"Charette K","year":"2012","journal-title":"Perfusion"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jtcvs.2017.09.146","article-title":"The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial","volume":"155","author":"Ad N","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jtcvs.2022.01.044","article-title":"Clinical impact of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial","volume":"166","author":"Garcia-Suarez J","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1051\/ject\/201850083","article-title":"Global cardioplegia practices: results from the global cardiopulmonary bypass survey","volume":"50","author":"Ali JM","year":"2018","journal-title":"J Extra Corpor Technol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ejcts.2009.09.030","article-title":"Warm versus cold cardioplegia for heart surgery: a meta-analysis","volume":"37","author":"Fan Y","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/0267659120942656","article-title":"Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review","volume":"36","author":"Whittaker A","year":"2021","journal-title":"Perfusion"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.asjsur.2021.09.032","article-title":"Comparison of del Nido cardioplegia vs. blood cardioplegia in adult aortic surgery: is the single-dose cardioplegia technique really advantageous?","volume":"45","author":"Eris C","year":"2022","journal-title":"Asian J Surg"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12024-020-00232-5","article-title":"Diagnostic role of postmortem CK-MB in cardiac death: a systematic review and meta-analysis","volume":"16","author":"Xu C","year":"2020","journal-title":"Forensic Sci Med Pathol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/02676591211031095","article-title":"Del Nido cardioplegia for myocardial protection in adult cardiac surgery: a systematic review and update meta-analysis","volume":"38","author":"Zhai K","year":"2023","journal-title":"Perfusion"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s13019-024-02853-1","article-title":"Comparative analysis of del Nido cardioplegia versus blood cardioplegia in isolate coronary artery bypass grafting","volume":"19","author":"Lee S","year":"2024","journal-title":"J Cardiothorac Surg"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025000300610&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:09:49Z","timestamp":1746184189000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025000300610&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025000300610"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20241451","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20241451"}}