{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:44:48Z","timestamp":1787845488481,"version":"build-2784847793"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to investigate independent risk factors for diversion colitis induced by the surgical interruption of fecal flow in the non-functional colon.  METHODS: We performed a retrospective study with 163 patients who underwent low anterior resections and created prophylactic ileostomies for rectal cancer between January 2014 and June 2023 at the Department of General Surgery, Air Force Medical University Tangdu Hospital. Colonoscopy results of the non-functional region of the distal colon and clinical variables were collected, including age, sex, body mass index, pathological tumor node metastasis staging, ileostomy method, diversion time, receiving radiotherapy or chemotherapy or not, suffering from preoperative inflammatory bowel disease or postoperative anastomotic leakage or not. Diagnosis of diversion colitis based on the results of the patients\u2019 colonoscopy results. Univariate analysis and multivariate analysis of diversion colitis-related risk factors were performed subsequently.  RESULTS: The morbidity of diversion colitis is 53.4% (87\/163) in our study. Multivariate analysis showed that risk factors for diversion colitis included single-lumen prophylactic ileostomy (63.2 vs. 30.3%, OR 4.481, 95%CI 1.897\u201310.584, p&lt;0.001), diversion time \u226590 days (79.3 vs. 40.8%, OR 4.474, 95%CI 1.849\u201310.826, p&lt;0.001), inflammatory bowel disease (17.2 vs. 3.9%, OR 7.491, 95%CI 1.839\u201330.507, p=0.005), radiotherapy (58.6 vs. 42.1%, OR 0.515, 95%CI 0.196\u20131.352, p=0.178).  CONCLUSION: These findings suggest that single-lumen prophylactic ileostomy, diversion time, and inflammatory bowel disease are independent risk factors for diversion colitis.<\/jats:p>","DOI":"10.1590\/1806-9282.20241590","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:08:02Z","timestamp":1746184082000},"source":"Crossref","is-referenced-by-count":1,"title":["Independent risk factors for diversion colitis: a retrospective case-control study"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-9830","authenticated-orcid":false,"given":"Di","family":"Wu","sequence":"first","affiliation":[{"name":"Air Force Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9272-5478","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"The 964th Hospital of the Joint Logistics Support Force,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7522-1361","authenticated-orcid":false,"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"The 964th Hospital of the Joint Logistics Support Force,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"9-10","key":"ref1","first-page":"216","article-title":"[Colorectal cancer]","volume":"173","author":"Zhang C","year":"2023","journal-title":"Wien Med Wochenschr"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10151-022-02739-1","article-title":"Outcomes of open vs laparoscopic vs robotic vs transanal total mesorectal excision (TME) for rectal cancer: a network meta-analysis","volume":"27","author":"Seow W","year":"2023","journal-title":"Tech 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rectal segment after diversion of the fecal stream in Crohn's disease: its implications for surgical management","volume":"7","author":"Korelitz BI","year":"1985","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3748\/wjg.v19.i4.542","article-title":"Relationship between diversion colitis and quality of life in rectal cancer","volume":"19","author":"Son DN","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5009\/gnl.2014.8.2.170","article-title":"Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study","volume":"8","author":"Baek SJ","year":"2014","journal-title":"Gut Liver"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1001819","DOI":"10.3389\/fonc.2023.1001819","article-title":"Interaction between the intestinal flora and the severity of diversion 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