{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:13:05Z","timestamp":1770286385741,"version":"3.49.0"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Bone mineral density is affected by many gene regions. Osteoporosis is a disease that occurs due to decreased bone mineral density and has a polygenetic multifactorial pathogenesis. The aim of this study was to examine the effect of gene variants in eight gene regions related to bone mineral density in patients diagnosed with osteopenia or osteoporosis.  METHODS: A total of 60 patients diagnosed with osteoporosis, 50 patients diagnosed with osteopenia, and 40 healthy volunteers (control group) were included in the study. Collagen type I alpha 1 1997G\/T, estrogen receptor \u03b1 PvuII, estrogen receptor \u03b1 XbaI, vitamin D receptor BsmI, lactase gene, osteoprotegerin G209A, osteoprotegerin T245G, and interleukin-6 G174C gene variants were analyzed.  RESULTS: No important difference was found in the distribution of collagen type I alpha 1 1997G\/T, estrogen receptor \u03b1 PvuII, estrogen receptor \u03b1 XbaI, vitamin D receptor BsmI, lactase gene T13910C, osteoprotegerin T245G, and interleukin-6 G174C gene variants between groups. A significant difference was detected between the distribution of osteoprotegerin G209A gene variants in the patient groups and the distribution of osteoprotegerin G209A gene variants in the control group. On the other hand, no important difference was detected in the distribution of osteoprotegerin G209A gene variants between patient groups.  CONCLUSION: The osteoprotegerin G209A gene variant may be associated with the risk of osteopenia and osteoporosis in the Turkish population. Other gene variants analyzed that affect bone mineral density were not associated with the risk of osteopenia and osteoporosis.<\/jats:p>","DOI":"10.1590\/1806-9282.20241624","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:07:26Z","timestamp":1746184046000},"source":"Crossref","is-referenced-by-count":1,"title":["The effect of eight different gene polymorphisms on osteopenia and osteoporosis in the Turkish population"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-7643","authenticated-orcid":false,"given":"Naim","family":"Uzun","sequence":"first","affiliation":[{"name":"Agri Ibrahim Cecen University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-8921","authenticated-orcid":false,"given":"Ahmet","family":"Kiziltunc","sequence":"additional","affiliation":[{"name":"Ataturk University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-2583","authenticated-orcid":false,"given":"Adem","family":"Keskin","sequence":"additional","affiliation":[{"name":"Ayd\u0131n Adnan Menderes University,  Turkey; Ayd\u0131n Adnan Menderes University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","article-title":"Postmenopausal osteoporosis: latest guidelines","volume":"50","author":"Arceo-Mendoza RM","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/endrev\/bnab028","article-title":"Secondary osteoporosis","volume":"43","author":"Ebeling PR","year":"2022","journal-title":"Endocr Rev"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1330.e13","DOI":"10.1016\/j.cell.2021.02.002","article-title":"Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption","volume":"184","author":"McDonald MM","year":"2021","journal-title":"Cell"},{"issue":"8","key":"ref4","first-page":"435","article-title":"[Update on fracture prevention after menopause]","volume":"78","author":"Thomasius F","year":"2021","journal-title":"Ther Umsch"},{"issue":"5","key":"ref5","first-page":"280","article-title":"Osteoporosis epidemiology using international cohorts","volume":"34","author":"Lorentzon M","year":"2022","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.1038\/s41467-021-27563-3","article-title":"Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta","volume":"12","author":"Chen Y","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.gene.2014.01.063","article-title":"Unliganded estrogen receptor \u03b1 stimulates bone sialoprotein gene expression","volume":"539","author":"Takai H","year":"2014","journal-title":"Gene"},{"issue":"2","key":"ref8","article-title":"Association of vitamin D receptor BsmI gene polymorphism with BMD Z-score in Iranian children and adolescents (9 - 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