{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:06:23Z","timestamp":1753887983138,"version":"3.41.2"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to investigate the correlation between the serum C-reactive protein\/albumin ratio and homocysteine\/high-density lipoprotein-cholesterol ratio with microvascular angina and assess their predictive value.  METHODS: A total of 70 patients diagnosed with microvascular angina comprised the observation group, while 68 patients with normal or minimal (&lt;50%) coronary stenosis and normal coronary blood flow formed the control group. Serum C-reactive protein, albumin, homocysteine, high-density lipoprotein-cholesterol, and other indexes were measured, and C-reactive protein\/albumin and homocysteine\/high-density lipoprotein-cholesterol ratios were calculated. Logistic regression, Pearson's correlation, and receiver operating characteristic analyses were conducted to identify independent risk factors for microvascular angina.  RESULTS: Significant differences in C-reactive protein, C-reactive protein\/albumin, homocysteine, and homocysteine\/high-density lipoprotein-cholesterol levels were found between the microvascular angina and control groups (p&lt;0.05). Multivariate logistic regression analysis showed that C-reactive protein, C-reactive protein\/albumin, homocysteine, and homocysteine\/high-density lipoprotein-cholesterol were independent risk factors for microvascular angina, with the risk increasing alongside elevated C-reactive protein\/albumin and homocysteine\/high-density lipoprotein-cholesterol levels. The receiver operating characteristic analysis demonstrated that C-reactive protein\/albumin, homocysteine\/high-density lipoprotein-cholesterol, and their combined use were predictive of microvascular angina, with the combined area under the curve value exceeding that of individual markers.  CONCLUSIONS: Elevated C-reactive protein\/albumin and homocysteine\/high-density lipoprotein-cholesterol offer predictive value for microvascular angina diagnosis, with the combination providing superior diagnostic accuracy over individual indicators, supporting early microvascular angina identification.<\/jats:p>","DOI":"10.1590\/1806-9282.20241772","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:01:58Z","timestamp":1750075318000},"source":"Crossref","is-referenced-by-count":0,"title":["The diagnostic value of serum C-reactive protein\/albumin and homocysteine\/high-density lipoprotein-cholesterol in coronary microvascular angina pectoris"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3295-5367","authenticated-orcid":false,"given":"Wenxin","family":"Zhao","sequence":"first","affiliation":[{"name":"Dalian Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1418-7309","authenticated-orcid":false,"given":"Xianfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fuwai Central China Cardiovascular Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0566-1648","authenticated-orcid":false,"given":"Zhongyan","family":"Li","sequence":"additional","affiliation":[{"name":"Dalian Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"899099","DOI":"10.3389\/fcvm.2022.899099","article-title":"Assessment and treatment for coronary microvascular dysfunction by contrast enhanced ultrasound","volume":"9","author":"Zhan J","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"8 Pt 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severity in patients with stable angina pectoris","volume":"32","author":"Karaba\u011f Y","year":"2018","journal-title":"J Clin Lab Anal"},{"issue":"3","key":"ref15","article-title":"Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study","volume":"8","author":"Liu B","year":"2018","journal-title":"BMJ Open"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biochi.2016.10.010","article-title":"Paraoxonase and atherosclerosis-related cardiovascular diseases","volume":"132","author":"Chistiakov DA","year":"2017","journal-title":"Biochimie"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica 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