{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:09:05Z","timestamp":1753888145014,"version":"3.41.2"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit, Yuzuncu Yil University","award":["TYD-2023-10445"],"award-info":[{"award-number":["TYD-2023-10445"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The diagnosis and prognosis of neonatal hypoxic-ischemic encephalopathy are established through clinical evidence and laboratory, imaging, and electrophysiological assessments of the nervous system. Netrin-1 was the first axon guidance molecule identified as a critical component of embryonic development in vertebrates and has a solid chemotropic function for angiogenesis, morphogenesis, cell migration, and axonal guidance. It was hypothesized that Netrin-1 will differ at different hypoxic-ischemic encephalopathy stages.  METHODS: This study included 75 hospitalized hypoxic-ischemic encephalopathy newborns and 48 healthy newborns born at the same hospital and followed up only by their mothers. Demographic, laboratory, and Netrin-1 data were evaluated for all hypoxic-ischemic encephalopathy stages.  RESULTS: Serum Netrin-1 concentrations were significantly greater in patients with moderate and severe hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia than in controls and patients with severe hypoxic-ischemic encephalopathy. However, serum Netrin-1 concentrations were not significantly greater in patients with mild hypoxic-ischemic encephalopathy than in controls. In 75 hypoxic-ischemic encephalopathy patients, correlations of Netrin-1 with lactate, uric acid, and lactate dehydrogenase were statistically significant (p=0.0001, 0.008, and 0.043, respectively).  CONCLUSION: Netrin-1 significantly increased in moderate and severe patients. Therefore, this marker could be a biomarker for staging hypoxic-ischemic encephalopathy and therapeutic hypothermia and predicting the prognosis of neonatal hypoxic-ischemic encephalopathy patients.<\/jats:p>","DOI":"10.1590\/1806-9282.20241889","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:03:40Z","timestamp":1750075420000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Netrin-1 in staging hypoxic ischemic encephalopathy"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-9496","authenticated-orcid":false,"given":"Nur","family":"Aycan","sequence":"first","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-9581","authenticated-orcid":false,"given":"Derya \u00c7ay","family":"Demir","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-0184","authenticated-orcid":false,"given":"Eyy\u00fcp","family":"Y\u00fcrekt\u00fcrk","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-7075","authenticated-orcid":false,"given":"Murat","family":"Ba\u015faranoglu","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-6883","authenticated-orcid":false,"given":"Serap","family":"Karaman","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-414X","authenticated-orcid":false,"given":"O\u011fuz","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1469-8749.2007.tb12627.x","article-title":"Definition and classification of cerebral palsy. 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