{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:07:04Z","timestamp":1784804824572,"version":"3.55.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the role of substance P in pruritus in patients with intrahepatic cholestasis of pregnancy.  METHODS: This prospective case\u2013control study was conducted on 50 intrahepatic cholestasis of pregnancy patients and 30 gestational age-matched healthy pregnant women. The groups were compared in terms of serum substance P concentrations, and the correlation between these concentrations and self-reported itching was evaluated in patients with intrahepatic cholestasis of pregnancy.  RESULTS: Serum substance P concentrations were higher in patients with intrahepatic cholestasis of pregnancy than in the control group (960 vs. 611 ng\/L; p=0.001). In intrahepatic cholestasis of pregnancy patients, there was a statistically significant positive correlation between the serum substance P concentration and both the Pruritus Severity Scale score (r=605, p&lt;0.001) and the visual analog scale score for pruritus (r=483, p&lt;0.001). On multivariable linear regression analysis, only the presence of intrahepatic cholestasis of pregnancy (pruritus) was statistically significantly associated with an increase in the serum substance P concentration (95%CI 145.06\u2013558.16 ng\/L; p=0.001).  CONCLUSION: The concentration of substance P is increased in patients with intrahepatic cholestasis of pregnancy and is correlated with the severity of the pruritus. While the precise role of elevated substance P levels in the etiology of intrahepatic cholestasis of pregnancy remains uncertain, it may contribute to the pathogenesis of pruritus through central and peripheral effects.<\/jats:p>","DOI":"10.1590\/1806-9282.20242025","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:03:39Z","timestamp":1750075419000},"source":"Crossref","is-referenced-by-count":1,"title":["Pruritus in intrahepatic cholestasis of pregnancy: the role of substance p"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-4660","authenticated-orcid":false,"given":"\u00d6mer G\u00f6khan","family":"Eyisoy","sequence":"first","affiliation":[{"name":"Zeynep Kamil Women and Children Diseases Training and Research Hospital Affiliated with the University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-4625","authenticated-orcid":false,"given":"\u00c7a\u011fda\u015f","family":"\u00d6zg\u00f6k\u00e7e","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Women and Children Diseases Training and Research Hospital Affiliated with the University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-6327","authenticated-orcid":false,"given":"\u00dcmit","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Women and Children Diseases Training and Research Hospital Affiliated with the University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-6472","authenticated-orcid":false,"given":"Sinem","family":"Tekin","sequence":"additional","affiliation":[{"name":"Haseki Training and Research Hospital Affiliated with the University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-4437","authenticated-orcid":false,"given":"Oya","family":"Demirci","sequence":"additional","affiliation":[{"name":"Zeynep Kamil Women and Children Diseases Training and Research Hospital Affiliated with the University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1111\/tog.12308","article-title":"Intrahepatic cholestasis of pregnancy","volume":"18","author":"Geenes V","year":"2016","journal-title":"Obstet Gynaecol"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/sj.jid.5700231","article-title":"Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus","volume":"126","author":"Steinhoff 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brain-derived neurotrophic factor and substance P","volume":"157","author":"Hon KL","year":"2007","journal-title":"Br J Dermatol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01.EWX.0000397890.41559.b2","article-title":"Substance P and pruritus in psoriasis","volume":"8","author":"Zaki MS","year":"2011","journal-title":"J Egypt Women's Dermatol Soc"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4103\/mmj.mmj_324_19","article-title":"Substance P: does it have a role in renal pruritus?","volume":"34","author":"El-Mohsen Montaser BA","year":"2021","journal-title":"Menoufia Med J"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11255-021-02929-0","article-title":"Evaluation of the causes affecting the development of pruritus in patients with peritoneal dialysis","volume":"54","author":"Koyuncu S","year":"2022","journal-title":"Int Urol 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