{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:16:16Z","timestamp":1761578176218,"version":"build-2065373602"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to assess the relationship between hypophosphatemia and osteoporosis in people living with HIV on antiretroviral therapy, and to identify risk factors associated with both conditions.  METHODS: This was a cross-sectional, analytical study of 96 patients at a clinic in Bel\u00e9m-PA. Data collection included serum phosphorus, calcium, vitamin D, parathyroid hormone, renal parameters, and bone mineral density (T-score). Student's t-test, Mann-Whitney U test, chi-square test, or Fisher's exact test was applied, as well as multiple logistic regression for hypophosphatemia and osteoporosis.  RESULTS: Of the 96 patients, 24 (25%) had hypophosphatemia, with a male predominance (75%). There was a statistically significant association (p&lt;0.05) between hypophosphatemia and longer duration of infection and use of antiretroviral therapy, as well as a higher prevalence in men. Regimens containing tenofovir disoproxil fumarate showed an increased risk of hypophosphatemia, although logistic regression did not confirm significance at the 5% level. As for osteoporosis, there was an association with female gender and age but no direct relationship with hypophosphatemia.  CONCLUSION: Hypophosphatemia was significantly associated with male gender, prolonged infection, and the use of antiretroviral therapy, especially regimens with tenofovir disoproxil fumarate. There was no statistical correlation between hypophosphatemia and osteoporosis, but female gender and advanced age were risk factors for the latter. These findings highlight the importance of monitoring bone and kidney parameters in people living with HIV, especially those on long-term tenofovir disoproxil fumarate, with a view to more effective preventive and therapeutic strategies.<\/jats:p>","DOI":"10.1590\/1806-9282.20250104","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:04:41Z","timestamp":1761577481000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of serum phosphorus levels and their relation with the development of osteoporosis in people living with HIV\/AIDS"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-0067","authenticated-orcid":false,"given":"Thirza Damasceno Ramos","family":"Oliva","sequence":"first","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3481-8890","authenticated-orcid":false,"given":"Isabella Mesquita Sfair","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8283-8500","authenticated-orcid":false,"given":"Jeremias Estevam","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6589-7262","authenticated-orcid":false,"given":"Kamylla Batista","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8499-6561","authenticated-orcid":false,"given":"Arthur Cavalcante","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-7806","authenticated-orcid":false,"given":"Rosana Maria Feio","family":"Libonati","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","first-page":"1017","article-title":"Osteoporosis: pathophysiology and therapeutic options","volume":"19","author":"F\u00f6ger-Samwald U","year":"2020","journal-title":"EXCLI J"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.18231\/j.ijcbr.2020.035","article-title":"Serum calcium and phosphorus levels in patients of HIV positive under the treatment","volume":"7","author":"Asha Kiran N","year":"2020","journal-title":"Int J Clin Biochem Res"},{"key":"ref3","article-title":"Low bone mineral density among HIV-infected patients in Brazil","volume":"59","author":"Chaba DCDS","year":"2017","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/jamasurg.2021.0528","article-title":"STROBE reporting guidelines for observational studies","volume":"156","author":"Ghaferi AA","year":"2021","journal-title":"JAMA Surg"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4274\/balkanmedj.galenos.2022.31102022","article-title":"Importance of sample size calculation and power analysis in scientific studies: an example from the balkan medical journal","volume":"39","author":"S\u00fct N","year":"2022","journal-title":"Balkan Med J"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.7954","article-title":"Comparison of overall and comorbidity-free life expectancy between insured adults with and without HIV infection, 2000-2016","volume":"3","author":"Marcus JL","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00223-022-00946-4","article-title":"Osteoporosis and HIV infection","volume":"110","author":"Biver E","year":"2022","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215575","article-title":"Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort","volume":"14","author":"Brito RM","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1468-1293.2010.00855.x","article-title":"Evaluation of glomerular filtration rate in HIV-1-infected patients before and after combined antiretroviral therapy exposure","volume":"12","author":"Tordato F","year":"2011","journal-title":"HIV Med"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jocd.2011.06.004","article-title":"Low bone mass prevalence, therapy type, and clinical risk factors in an HIV-infected Brazilian population","volume":"14","author":"Pinto Neto LF","year":"2011","journal-title":"J Clin Densitom"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1089\/aid.2013.0252","article-title":"Long-term use of protease inhibitors is associated with bone mineral density loss","volume":"30","author":"Kinai E","year":"2014","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"675385","DOI":"10.3389\/fendo.2021.675385","article-title":"The role of osteoclast energy metabolism in the occurrence and development of osteoporosis","volume":"12","author":"Da W","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00424-008-0580-8","article-title":"Regulation of phosphate transport in proximal tubules","volume":"458","author":"Biber J","year":"2009","journal-title":"Pflugers Arch"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/QAI.0000000000003274","article-title":"Fracture risk and association with TDF use among people with HIV in large integrated health systems","volume":"94","author":"Hechter RC","year":"2023","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s40264-018-0665-z","article-title":"Osteoporosis-related fractures in HIV-infected patients receiving long-term tenofovir disoproxil fumarate: an observational cohort study","volume":"41","author":"Komatsu A","year":"2018","journal-title":"Drug Saf"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/1806-9282.64.05.469","article-title":"Are women living with HIV prone to osteoporosis in postmenopause? A systematic review","volume":"64","author":"Cezarino PYA","year":"2018","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"3","key":"ref17","first-page":"238","article-title":"Osteoporosis: common questions and answers","volume":"107","author":"Harris K","year":"2023","journal-title":"Am Fam Physician"},{"issue":"15","key":"ref18","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.3390\/nu15153494","article-title":"Changes in food consumption in postmenopausal women during the COVID-19 pandemic: a longitudinal study","volume":"15","author":"Noll PRES","year":"2023","journal-title":"Nutrients"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025001000601&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:04:43Z","timestamp":1761577483000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025001000601&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025001000601"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20250104","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20250104"}}