{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:08Z","timestamp":1787023088003,"version":"build-2736575974"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: This study aims to investigate the relationship between vascular endothelial growth factor gene polymorphisms and Crimean\u2013Congo hemorrhagic fever  METHODS: A total of 130 serum samples were analyzed, including 60 patients diagnosed with Crimean\u2013Congo hemorrhagic fever and 70 healthy controls. Genetic analyses were performed using polymerase chain reaction and restriction fragment length polymorphism techniques.  RESULTS: Significant differences were observed between patient and control groups in terms of vascular endothelial growth factor \u2212460 C\/T and -ID (18 bp) polymorphisms.  CONCLUSION: Vascular endothelial growth factor gene polymorphisms may contribute to genetic susceptibility to Crimean\u2013Congo hemorrhagic fever. Further studies with larger sample sizes are recommended to support these findings.<\/jats:p>","DOI":"10.1590\/1806-9282.20250147","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T13:23:03Z","timestamp":1754659383000},"source":"Crossref","is-referenced-by-count":1,"title":["Relationship between vascular endothelial growth factor gene polymorphisms and Crimean\u2013Congo hemorrhagic fever"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-4799","authenticated-orcid":false,"given":"Umut Safiye \u015eay","family":"Co\u015fkun","sequence":"first","affiliation":[{"name":"Tokat Gaziosmanpa\u015fa University,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-3964","authenticated-orcid":false,"given":"Serb\u00fclent","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Ondokuz May\u0131s University,  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