{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T19:18:12Z","timestamp":1758309492940,"version":"3.44.0"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Hepatitis C virus prevalence is higher in hemodialysis patients than in the general population. It is recommended that patients who are detected to be anti-hepatitis C virus seropositive should be dialyzed in separate machines. In patients requiring urgent hemodialysis treatment, anti-hepatitis C virus seropositivity may cause confusion and delay in dialysis sessions.  METHODS: The aim of the study was to determine the most appropriate signal-to-cutoff value to predict hepatitis C virus viremia in hemodialysis patients and to evaluate the effect of genotype differences. A total of 12,280 anti-hepatitis C virus results from hemodialysis patients between 2021 and 2024 were examined.  RESULTS: The mean age of 563 patients included in the study was 57 years, and 330 (58.6%) were male. Of the 563 patients, 68 (12.07%) were true hepatitis C virus patients. The mean age of hepatitis C virus-ribonucleic acid(+) patients was higher than that of the hepatitis C virus-ribonucleic acid(-) group (p&lt;0.018). Anti-hepatitis C virus signal-to-cutoff value was &gt;1 in all true hepatitis C virus patients. Hepatitis C virus-ribonucleic acid was accepted as the gold standard to determine the best threshold value in receiver operating characteristic curve analysis, and the most appropriate signal-to-cutoff value was found to be 2.23. Sensitivity was 98.5%, specificity was 87.1%, positive predictive value was 51.2%, and negative predictive value was 99.8%. 49 (85.96%) of the patients were identified as genotype(-1; the most common subtype was genotype-1b (n=43).  CONCLUSION: Anti-hepatitis C virus negativity is a reliable result in hemodialysis patients. If anti-hepatitis C virus signal-to-cutoff \u22652.23 is detected, confirmation by direct hepatitis C virus-ribonucleic acid testing is recommended. In hemodialysis patients with anti-hepatitis C virus signal-to-cutoff values between 1 and 2.23, false positivity should be considered first, and confirmatory tests should be performed if anti-hepatitis C virus is reactive in a second sample.<\/jats:p>","DOI":"10.1590\/1806-9282.20250184","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:04:48Z","timestamp":1758294288000},"source":"Crossref","is-referenced-by-count":0,"title":["Anti-hepatitis C virus threshold value in predicting hepatitis C virus viremia in hemodialysis patients"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9952-1721","authenticated-orcid":false,"given":"Vahibe Ayd\u0131n","family":"Sar\u0131kaya","sequence":"first","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-8145","authenticated-orcid":false,"given":"U\u011fur","family":"Ayan","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Prof. Dr. S\u00fcleyman Yal\u00e7\u0131n City Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-1337","authenticated-orcid":false,"given":"Sebahat","family":"Aksaray","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1186-1280","authenticated-orcid":false,"given":"Selami","family":"Erdin\u00e7","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-1927","authenticated-orcid":false,"given":"Burak","family":"Sar\u0131kaya","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-2525","authenticated-orcid":false,"given":"Recep","family":"Bal\u0131k","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6613","authenticated-orcid":false,"given":"Seniha","family":"\u015eenbayrak","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-3665","authenticated-orcid":false,"given":"Serpil","family":"Erol","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-1262","authenticated-orcid":false,"given":"Asuman","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-8266","authenticated-orcid":false,"given":"Nurg\u00fcl","family":"Ceran","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital,  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