{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:14:07Z","timestamp":1758359647937,"version":"3.44.0"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to compare the evolution of high-grade human papillomavirus-induced cervical lesions between human immunodeficiency virus-positive and human immunodeficiency virus-negative women.  METHODS: Human immunodeficiency virus-positive and human immunodeficiency virus-negative women were enrolled in a retrospective cohort study after undergoing large-loop excision of the transformation zone between January 2008 and December 2017 as participants in the high-grade cervical lesion screening program. The evolution of human papillomavirus lesions induced in human immunodeficiency virus-infected women was evaluated in comparison with the general population. The following potentially confounding variables were examined: age at treatment and at the end of follow-up, histologic grade of treated intraepithelial disease, compromised margins, adequacy of colposcopy during follow-up, and recurrence of histopathologic diagnosis of high-grade squamous intraepithelial lesion.  RESULTS: Of the 195 women, 51 were human immunodeficiency virus-positive (26.2%) and 144 were human immunodeficiency virus-negative (73.8%). Age of menarche (11.8\u00b11.5) and sexarche (14.5\u00b12.2) were earlier in human immunodeficiency virus-positive women (p=0.021 and 0.006, respectively). Parity (2.35\u00b1109) and number of pregnancies (2.86\u00b11.47) were higher in human immunodeficiency virus-positive women (p=0.027 and 0.018, respectively). The prevalence of incomplete schooling was lower in human immunodeficiency virus-positive women (47.1 vs. 19.8%, p=0.002). Smoking was more common in human immunodeficiency virus-positive women (58.8 vs. 31.9%, p=0.001). Compromised surgical margins were found in 33.3% of human immunodeficiency virus-positive and 16.7% of human immunodeficiency virus-negative women (p&lt;0.001). The risk of recurrence was 37.3% in human immunodeficiency virus-positive and 13.9% in human immunodeficiency virus-negative women (p&lt;0.001). Cumulative survival over months was shortened in human immunodeficiency virus-positive women (p&lt;0.001).  CONCLUSION: human immunodeficiency virus-positive women in this cohort had a significantly higher risk of recurrence than human immunodeficiency virus-negative women in addition to shorter overall survival.<\/jats:p>","DOI":"10.1590\/1806-9282.20250214","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:03:59Z","timestamp":1758294239000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of high-grade human papillomavirus-induced cervical lesions between human immunodeficiency virus-positive and human immunodeficiency virus-negative women"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1891-815X","authenticated-orcid":false,"given":"Fl\u00e1via Werner da Rocha","family":"Jesuino","sequence":"first","affiliation":[{"name":"A.C. Camargo C\u00e2ncer Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil; Universidade Municipal de S\u00e3o Caetano do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-166X","authenticated-orcid":false,"given":"Levon","family":"Badiglian-Filho","sequence":"additional","affiliation":[{"name":"A.C. Camargo C\u00e2ncer Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1634\/theoncologist.2017-0444","article-title":"Barriers and facilitators to cervical cancer screening, diagnosis, follow-up care and treatment: perspectives of human immunodeficiency virus-positive women and health care practitioners in tanzania","volume":"24","author":"Bateman LB","year":"2019","journal-title":"Oncologist"},{"issue":"24","key":"ref2","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1001\/jama.286.24.3106","article-title":"Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia","volume":"286","author":"Schlecht NF","year":"2001","journal-title":"JAMA"},{"issue":"3","key":"ref3","first-page":"351","article-title":"April 1-3, 1996","volume":"66","year":"1997","journal-title":"Gynecol Oncol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers JM","year":"1999","journal-title":"J Pathol"},{"issue":"4","key":"ref5","article-title":"Genotype-specific methylation of HPV in cervical intraepithelial neoplasia","volume":"28","author":"Hsu YW","year":"2017","journal-title":"J Gynecol Oncol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/aje\/kwf180","article-title":"Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students","volume":"157","author":"Winer RL","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"6","key":"ref7","first-page":"345","article-title":"[Association between CD4+ T-cell count and intraepithelial cervical neoplasia diagnosed by histopathology in HIV-infected women]","volume":"28","author":"Zimmermam JB","year":"2006","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/jnci\/djj010","article-title":"Incident high-grade squamous intraepithelial lesions in Senegalese women with and without human immunodeficiency virus type 1 (HIV-1) and HIV-2","volume":"98","author":"Hawes SE","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"ref9","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray F","year":"2018","journal-title":"CA Cancer J Clin"},{"year":"2021","series-title":"Estat\u00edsticas globais sobre 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M","year":"2017","journal-title":"Cancer Med"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1590\/0104-1169.3364","article-title":"Sociodemographic and clinical factors of women with HPV and their association with HIV","volume":"23","author":"Gaspar J","year":"2015","journal-title":"Rev Lat Am Enfermagem"},{"issue":"4","key":"ref15","article-title":"Cancer [Risk in patients living with HIV\/AIDS: systematic review]","volume":"66","author":"Leo Nogueira Costa L","year":"2020","journal-title":"Rev Bras Cancerol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bpobgyn.2017.08.015","article-title":"The natural history of human papillomavirus infection","volume":"47","author":"Sanjos\u00e9 S","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/cid\/ciy1123","article-title":"Residual or recurrent precancerous lesions after treatment of cervical lesions in human immunodeficiency virus-infected women: a systematic review and meta-analysis of treatment failure","volume":"69","author":"Debeaudrap P","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref18","first-page":"405","article-title":"Recurrence of cervical intraepithelial neoplasia in human immunodeficiency virus-infected women treated by means of electrosurgical excision of the transformation zone (LLETZ) in Rio de Janeiro, Brazil","volume":"131","author":"Russomano F","year":"2013","journal-title":"Sao Paulo Med J"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12981-021-00371-x","article-title":"Should the management of high grade cervical squamous intraepithelial lesion (HSIL) be different in HIV-positive women?","volume":"18","author":"Gilles C","year":"2021","journal-title":"AIDS Res Ther"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/QAD.0000000000001853","article-title":"Suppressive antiretroviral therapy associates with effective treatment of high-grade cervical intraepithelial neoplasia","volume":"32","author":"Carlander C","year":"2018","journal-title":"AIDS"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijrobp.2018.01.067","article-title":"Impact of human immunodeficiency virus infection on survival and acute toxicities from chemoradiation therapy for cervical cancer patients in a limited-resource setting","volume":"101","author":"Grover S","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025000800605&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:04:02Z","timestamp":1758294242000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025000800605&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":21,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025000800605"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20250214","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20250214"}}