{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:12:23Z","timestamp":1787083943171,"version":"build-2736575974"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Robotic surgery has been gaining attention because of the physical and metabolic morbidity of the conventional open technique. The systemic immune-inflammation index has emerged as a recent and more reliable biomarker. In our single-center retrospective cohort study, we investigate systemic immune-inflammation index in robotic gastrectomy in order to show the advantageous effect on the immune system, which we think is the first study in the literature.  METHODS: The study involved patients from a high-volume center for 32 months. The patients were allocated into three groups: patients with robotic (1), laparoscopic (2), and open surgery (3). Venous blood was derived on the postoperative 24th hour. The systemic immune-inflammation index scores were compared in three groups in terms of Group 1 vs. Groups 2 and 3, Groups 1 and 2 vs. Group 3, and compared with platelet-lymphocyte ratio, neutrophil\u2013lymphocyte ratio scores.  RESULTS: Robotic surgery was performed in 55 patients, laparoscopic surgery in 13 patients, and open surgery in 248 patients. In the comparison of minimally invasive surgery (Groups 1+2) vs. open surgery (Group 3), systemic immune-inflammation index, platelet-lymphocyte ratio, and neutrophil\u2013lymphocyte ratio were found to be significantly lower in the minimally invasive surgery group (p&lt;0.05). The comparison between robotic surgery patients (Group 1) and patients with laparoscopy\/open surgery (groups 2 and 3) showed that systemic immune-inflammation index, platelet-lymphocyte ratio, and neutrophil\u2013lymphocyte ratio were significantly lower in Group 1 (p&lt;0.05). neutrophil\u2013lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index values were analyzed by receiver operating characteristic curve test, and the area under curve value of systemic immune-inflammation index was found to be higher in minimally invasive surgery group (robotic+laparoscopic) (p&lt;0.05).  CONCLUSION: The study reveals the superiority of robotic gastrectomy as a more feasible and high-quality procedure over conventional techniques in terms of better preservation of immune system function using a reliable and noninvasive serum biomarker.<\/jats:p>","DOI":"10.1590\/1806-9282.20250258","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T13:22:02Z","timestamp":1754659322000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of robotic surgery on systemic immune-inflammation index in gastric cancer patients: a retrospective cohort study"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-6896","authenticated-orcid":false,"given":"Yi\u011fit","family":"D\u00fczk\u00f6yl\u00fc","sequence":"first","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8168-3432","authenticated-orcid":false,"given":"P\u0131nar","family":"G\u00fclcan","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-6726","authenticated-orcid":false,"given":"H\u00fcsn\u00fc Ozan","family":"\u015eevik","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-7949","authenticated-orcid":false,"given":"O\u011fuzhan","family":"Tekin","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-4954","authenticated-orcid":false,"given":"H\u00fcr\u00fc Ceren","family":"G\u00f6kduman","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-0526","authenticated-orcid":false,"given":"Erdal","family":"Karak\u00f6se","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-7774","authenticated-orcid":false,"given":"Sercan","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-6476","authenticated-orcid":false,"given":"Zafer","family":"Teke","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","series-title":"Japanese gastric cancer treatment guidelines 2021","first-page":"1","volume":"26","year":"2023","edition":"6th edition"},{"issue":"13","key":"ref3","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.3390\/jcm11133590","article-title":"Laparoscopic versus open surgery for gastric 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