{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:13:13Z","timestamp":1765811593418,"version":"3.48.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais and the Funda\u00e7\u00e3o Educacional Lucas Machado"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the kinetics of immunoglobulin G and neutralizing antibody responses following vaccination with CoronaVac in healthcare professionals.  METHODS: A cohort of 35 healthcare professionals was recruited, and blood samples were collected to assess immunoglobulin G detection and neutralizing antibodies against severe acute respiratory syndrome coronavirus 2.  RESULTS: Immunoglobulin G seroconversion peaked at D30 (68.2%, 15\/22), followed by stabilization at D48 and D90. Logistic regression confirmed a significant association between time post-vaccination and seroconversion (p=0.0043). Neutralizing antibody analysis showed a stable detection rate for Nab V1 (Wuhan and B.1.1.7) between D48 and D90 (p&gt;0.9999), while Nab V2 (B.1.351 and P.1) remained consistently lower. Among immunoglobulin G-positive individuals, 92.3% (12\/13) had neutralizing antibodies at D48, decreasing to 42.8% (6\/14) at D90.  CONCLUSION: CoronaVac effectively induces immunoglobulin G seroconversion, peaking at D30. However, neutralizing responses to emerging variants were lower, suggesting the need for booster doses to maintain immunity. These findings highlight the importance of monitoring vaccine-induced immunity over time.<\/jats:p>","DOI":"10.1590\/1806-9282.20250360","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:08:13Z","timestamp":1765811293000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin G and neutralizing antibody response after CoronaVac"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1727-5421","authenticated-orcid":false,"given":"Pedro Borges Carvalho de","family":"Assis","sequence":"first","affiliation":[{"name":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5111-7764","authenticated-orcid":false,"given":"Luca Nascimento","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9055-6523","authenticated-orcid":false,"given":"Fernanda Medeiros Vale","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-3775","authenticated-orcid":false,"given":"Paula Fernandes","family":"T\u00e1vora","sequence":"additional","affiliation":[{"name":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-2164","authenticated-orcid":false,"given":"Luara Isabela dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","first-page":"157","article-title":"WHO declares COVID-19 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00095-21","article-title":"Pathogenesis, symptomatology, and transmission of SARS-CoV-2 through analysis of viral genomics and structure","volume":"6","author":"Rando HM","year":"2021","journal-title":"mSystems"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011168","article-title":"Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements","volume":"19","author":"Snouwaert JN","year":"2023","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref4","first-page":"10","article-title":"Perspectives on 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