{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:09:55Z","timestamp":1765811395240,"version":"3.48.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Crimean-Congo hemorrhagic fever is a severe viral hemorrhagic disease transmitted by ticks and characterized by fever, malaise, and hemorrhages. This research was designed to measure serum neopterin concentrations in patients with Crimean-Congo hemorrhagic fever and to assess how these levels are associated with the disease's progression.  METHODS: A total of 60 patients and 25 healthy controls, monitored at the Atat\u00fcrk University Infectious Diseases Clinic from March 2009 to September 2010, were enrolled in the study. Serum neopterin concentrations were determined using an ELISA method, and statistical tests were conducted to explore their association with various clinical parameters.  RESULTS: The results indicated a significant increase in serum neopterin levels in patients with Crimean-Congo hemorrhagic fever, and this rise was strongly linked to disease prognosis. Additionally, research has established that serum neopterin levels play a crucial role in determining patient outcomes, including survival and mortality.  CONCLUSION: This study has demonstrated that neopterin levels can be used not only to track disease progression but also as a predictor of prognosis. Future research should delve deeper into the role of this biomarker in disease management.<\/jats:p>","DOI":"10.1590\/1806-9282.20250488","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:07:04Z","timestamp":1765811224000},"source":"Crossref","is-referenced-by-count":0,"title":["Crimean-Congo hemorrhagic fever: serum neopterin levels and their relationship with clinical course"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-2560","authenticated-orcid":false,"given":"Mustafa","family":"Usanmaz","sequence":"first","affiliation":[{"name":"Samsun University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ijid.2008.07.021","article-title":"The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002-2007","volume":"13","author":"Yilmaz GR","year":"2009","journal-title":"Int J Infect Dis"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1473-3099(06)70435-2","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","author":"Erg\u00f6n\u00fcl O","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5798\/dicletip.1360703","article-title":"K\u0131r\u0131m Kongo Kanamal\u0131 Ate\u015fi Tan\u0131l\u0131 Hastalar\u0131n Epidemiyolojik, Klinik ve Laboratuvar \u00d6zelliklerinin De\u011ferlendirilmesi: Tek Merkez Deneyimi","author":"\u00c7i\u00e7ek Y","year":"2023","journal-title":"Dicle Med J"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.antiviral.2004.08.001","article-title":"Crimean-Congo hemorrhagic fever","volume":"64","author":"Whitehouse CA","year":"2004","journal-title":"Antiviral Res"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijid.2007.09.010","article-title":"Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality","volume":"12","author":"Cevik MA","year":"2008","journal-title":"Int J Infect Dis"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/jmv.24864","article-title":"Cytokine response in Crimean-Congo hemorrhagic fever virus infection","volume":"89","author":"Erg\u00f6n\u00fcl \u00d6","year":"2017","journal-title":"J Med Virol"},{"issue":"5","key":"ref7","first-page":"854","article-title":"Crimean-Congo hemorrhagic fever virus for clinicians-epidemiology, clinical manifestations, and prevention","volume":"30","author":"Frank MG","year":"2024","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"ref8","article-title":"Crimean-Congo hemorrhagic fever: an emerging viral infection in India, revisited and lessons learned","volume":"15","author":"Patel AA","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4266\/acc.2023.00024","article-title":"Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome","volume":"38","author":"Kember I","year":"2023","journal-title":"Acute Crit Care"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3390\/v13061040","article-title":"Central nervous system and ocular manifestations in Puumala Hantavirus infection","volume":"13","author":"Hautala N","year":"2021","journal-title":"Viruses"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/JIR.S290264","article-title":"Neopterin: a promising candidate biomarker for severe COVID-19","volume":"14","author":"Hailemichael W","year":"2021","journal-title":"J Inflamm Res"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4269\/ajtmh.1987.36.120","article-title":"Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa","volume":"36","author":"Swanepoel R","year":"1987","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jinf.2008.03.006","article-title":"High serum levels of neopterin in patients with Crimean-Congo hemorrhagic fever and its relation with mortality","volume":"56","author":"Onguru P","year":"2008","journal-title":"J Infect"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/20477724.2021.2012921","article-title":"Which scoring system is effective in predicting mortality in patients with Crimean Congo hemorrhagic fever? 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