{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:25:59Z","timestamp":1760747159733,"version":"build-2065373602"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The relationship between the number of lymph nodes removed and survival was investigated in patients undergoing radical gastrectomy and D2 lymph node dissection for gastric cancer.  METHODS: Patients who underwent gastrectomy and D2 lymph node dissection were analyzed. The cases were evaluated based on age, sex, tumor stage, number of removed lymph nodes, operation duration, presence of comorbidities, tumor status at the surgical margin, lymphovascular invasion, and perineural invasion. Survival analyses at 1 and 3 years were conducted.  RESULTS: The 1-year survival rate was 73%, and the 3-year survival rate was 40.4%. Factors associated with 1-year survival included age \u226570 years, the number of removed lymph nodes &lt;35, and the presence of lymphovascular invasion, which negatively impacted survival. Age \u226570 years reduced survival by 3.7 times, the number of lymph nodes removed &lt;35 reduced survival by 3.3 times, and the presence of lymphovascular invasion reduced survival by 4.6 times. For 3-year survival, age affected survival by 4.1 times, and tumor presence at the surgical margin affected survival by 2.85 times. A positive correlation was found between the number of removed lymph nodes and survival (p=0.006).  CONCLUSION: Lymph node dissection should be performed according to guidelines, and efforts should be made to increase the number of removed lymph nodes.<\/jats:p>","DOI":"10.1590\/1806-9282.20250506","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T15:05:09Z","timestamp":1760713509000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of the number of lymph nodes removed with D2 lymph node dissection on survival in gastric cancer"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7820-9088","authenticated-orcid":false,"given":"Orhan","family":"\u00dcreyen","sequence":"first","affiliation":[{"name":"University of Health Sciences Turkey,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-3133","authenticated-orcid":false,"given":"Emrehan","family":"\u0130nci","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-485X","authenticated-orcid":false,"given":"Hatice","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Dokuz Eylul University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0572-8713","authenticated-orcid":false,"given":"Merve Hamza\u00e7elebio\u011flu","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-0610","authenticated-orcid":false,"given":"Asuman","family":"Argon","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-9709","authenticated-orcid":false,"given":"Enver","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1245\/s10434-024-16545-6","article-title":"D2 lymphadenectomy for gastric cancer: advancements and technical considerations","volume":"32","author":"Dehal A","year":"2025","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1186\/s12885-023-11138-0","article-title":"The minimum number of examined lymph nodes was 24 for optimal survival of pathological T2-4 gastric cancer: a multi-center, hospital-based study covering 20 years of data","volume":"23","author":"Zhao L","year":"2023","journal-title":"BMC Cancer"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4240\/wjgs.v14.i11.1230","article-title":"Metastatic lymph nodes and prognosis assessed by the number of retrieved lymph nodes in gastric cancer","volume":"14","author":"Wang H","year":"2022","journal-title":"World J Gastrointest Surg"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10120-022-01331-8","article-title":"Japanese gastric cancer treatment guidelines 2021","volume":"26","year":"2023","journal-title":"Gastric Cancer"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.6004\/jnccn.2022.0008","article-title":"Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ajani JA","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"539030","DOI":"10.3389\/fonc.2020.539030","article-title":"Importance of examined lymph node number in accurate staging and enhanced survival in resected gastric adenocarcinoma-the more, the better? 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