{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:10:10Z","timestamp":1765811410092,"version":"3.48.0"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Atat\u00fcrk University Scientific Research Projects Commission","award":["TTU-2021-9613"],"award-info":[{"award-number":["TTU-2021-9613"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: In obesity, the fat storage in the body increases excessively and affects the whole metabolism.  METHODS: Sixty-two obese patients were included in the study. The effect of weight loss, which was achieved with a 3-month diet\/exercise program, on the following analytes was investigated; serum total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triacylglycerol, triglycerides (TAG), glucose, resistin, apelin, and a transcription factor sterol regulatory element binding protein-1c, and blood hemoglobin A1c. Basal (prediet\/exercise) levels of analytes were taken as control values, and they were compared to the postdiet\/exercise levels.  RESULTS: After the 3-month diet\/exercise program, apelin, hemoglobin A1c, and triacylglycerol, triglycerides levels decreased compared to basal levels, and those of sterol regulatory element binding protein-1c, glucose, and low-density lipoprotein-cholesterol increased.  CONCLUSION: Considering the insulin-like effects of apelin, high levels of apelin in prediet\/exercise phase can be interpreted as a kind of resistance to apelin, and the decreased postdiet\/exercise apelin levels as a kind of normalization of it. The decrease in hemoglobin A1c and triacylglycerol, triglycerides levels following weight loss can be appreciated. High basal serum sterol regulatory element binding protein-1c levels suggest an increase in lipogenesis. The increases in glucose and low-density lipoprotein-cholesterol after diet\/exercise program remain in a physiological range. However, we think that a longer diet\/exercise follow-up in a larger population will further elaborate on the issue.<\/jats:p>","DOI":"10.1590\/1806-9282.20250751","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:07:38Z","timestamp":1765811258000},"source":"Crossref","is-referenced-by-count":0,"title":["Relationship between obesity and serum resistin, apelin, and sterol regulatory element binding protein-1c levels: the changes in the analyte levels durin g weight loss in obese patients"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-5532","authenticated-orcid":false,"given":"Sena","family":"Erduhan","sequence":"first","affiliation":[{"name":"Ataturk University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-9954","authenticated-orcid":false,"given":"Ebubekir","family":"Bakan","sequence":"additional","affiliation":[{"name":"Ataturk 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