{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:57:34Z","timestamp":1776686254519,"version":"3.51.2"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the levels of nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin in patients undergoing coronary artery bypass grafting and explore their potential diagnostic roles.  METHODS: The study involved 43 coronary artery disease patients undergoing coronary artery bypass grafting and 43 age- and sex-matched healthy controls. Plasma levels of nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin were quantified by enzyme-linked immunosorbent assay. Statistical analyses were conducted using SPSS v25.0, with significance set at p&lt;0.05.  RESULTS: Nuclear factor erythroid 2 related factor 2 levels were significantly reduced, while tumor necrosis factor alpha and interleukin-40 were elevated in coronary artery disease patients (p&lt;0.001, p=0.003, p=0.001). Endorepellin levels did not differ significantly (p=0.120). Nuclear factor erythroid 2 related factor 2 correlated inversely with tumor necrosis factor alpha and interleukin-40; tumor necrosis factor alpha and interleukin-40 showed a positive correlation. Regression identified nuclear factor erythroid 2 related factor 2 as a tumor necrosis factor alpha predictor. Principal component analysis distinguished patients from controls based on biomarker profiles. These findings reflect enhanced inflammation and impaired antioxidant defense in coronary artery disease. Interleukin-40 may serve as a novel inflammatory biomarker; endorepellin's unchanged levels suggest localized vascular effects.  CONCLUSION: Nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, and interleukin-40 emerged as significant biomarkers reflecting the inflammatory and oxidative stress mechanisms associated with coronary artery disease. Interleukin-40 and endorepellin may offer new insights into disease mechanisms and warrant further research.<\/jats:p>","DOI":"10.1590\/1806-9282.20251054","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:08:50Z","timestamp":1776683330000},"source":"Crossref","is-referenced-by-count":0,"title":["Nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin levels in patients undergoing coronary artery bypass grafting"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-7830","authenticated-orcid":false,"given":"Re\u015fat","family":"Dikme","sequence":"first","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":false,"given":"\u0130smail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-6035","authenticated-orcid":false,"given":"Mehmet Salih","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Harran University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"122007","DOI":"10.1016\/j.lfs.2023.122007","article-title":"The crosstalk between Nrf2 and NF-\u03baB pathways in coronary artery disease: can it be regulated by SIRT6?","volume":"330","author":"Casper E","year":"2023","journal-title":"Life Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.redox.2016.06.004","article-title":"A biphasic effect of TNF-\u03b1 in regulation of the Keap1\/Nrf2 pathway in cardiomyocytes","volume":"9","author":"Shanmugam G","year":"2016","journal-title":"Redox 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