{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:57:20Z","timestamp":1777301840398,"version":"3.51.4"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  BACKGROUND: Juvenile idiopathic arthritis is the most common chronic rheumatic disease of childhood, with a significant genetic component. Polymorphisms in proinflammatory cytokine genes are potential contributors to disease susceptibility. The aim of this study was to investigate the association between tumor necrosis factor-alpha (TNF-\u03b1)-308G&gt;A (rs1800629), interleukin-1 beta (IL-1\u03b2)-511C&gt;T (rs16944), and interleukin-6 (IL-6)-174G&gt;C (rs1800795) variants and juvenile idiopathic arthritis in a Turkish cohort.  METHODS: A case\u2013control study was conducted involving 57 juvenile idiopathic arthritis patients and 50 age- and sex-matched healthy controls. Genotyping was performed using polymerase chain reaction\u2013restriction fragment length polymorphism. Genotype and allele distributions were compared between groups, and associations with clinical parameters (erythrocyte sedimentation rate, C-reactive protein, disease subtype) were assessed.  RESULTS: A significant association was found between the IL-1\u03b2-511C&gt;T polymorphism and juvenile idiopathic arthritis. The CC genotype was significantly more frequent in patients compared to controls (24.6 vs. 2.0%; p=0.004), and the C allele demonstrated a trend toward association (p=0.051). In contrast, no significant differences were observed in the genotype or allele frequencies of the TNF-\u03b1-308G&gt;A or IL-6-174G&gt;C variants between patients and controls. Furthermore, none of the studied polymorphisms were associated with erythrocyte sedimentation rate, C-reactive protein levels, or specific disease subtypes.  CONCLUSION: This study identifies the IL-1\u03b2-511C&gt;T polymorphism as a significant risk factor for juvenile idiopathic arthritis in the Turkish population, underscoring the role of the IL-1 pathway in disease pathogenesis. These findings contribute to the understanding of the ethnic-specific genetic architecture of juvenile idiopathic arthritis and suggest IL-1\u03b2 as a potential candidate for further functional and pharmacogenetic studies.<\/jats:p>","DOI":"10.1590\/1806-9282.20251421","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:09:45Z","timestamp":1776686985000},"source":"Crossref","is-referenced-by-count":0,"title":["The interleukin-1 beta 511C&gt;T polymorphism is associated with susceptibility to juvenile idiopathic arthritis in a Turkish population"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9082-6804","authenticated-orcid":false,"given":"Seyda","family":"Dogantan","sequence":"first","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0087","authenticated-orcid":false,"given":"Yasemin","family":"Oyaci","sequence":"additional","affiliation":[{"name":"Istanbul University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-2480","authenticated-orcid":false,"given":"Figen","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-1535","authenticated-orcid":false,"given":"Sevde Hasano\u011flu","family":"Sayin","sequence":"additional","affiliation":[{"name":"Istanbul University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-4049","authenticated-orcid":false,"given":"Emel Hatun 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