{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:56:15Z","timestamp":1781520975389,"version":"3.54.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to investigate the relationship between intrahepatic cholestasis of pregnancy and maternal nutritional intake, and to evaluate the impact of maternal nutritional status on maternal and fetal outcomes.  METHODS: This prospective case-control study enrolled 38 women with intrahepatic cholestasis of pregnancy and 76 age- and body mass index-matched controls between 2022 and 2023. Dietary intake was assessed using 24-h recall interviews and a 60-item food frequency questionnaire. Nutrient adequacy was calculated relative to age- and pregnancy-specific Dietary Reference Intakes. Maternal anthropometrics and gestational weight gain were recorded, alongside maternal and neonatal outcomes.  RESULTS: Women with intrahepatic cholestasis of pregnancy had significantly lower energy intake (p=0.004) and gestational weight gain (p&lt;0.001). Nutrient adequacy analyses indicated comprehensive deficiencies, with significantly lower adequacy for energy, protein, fiber, folate, magnesium, potassium, and iron (all p&lt;0.01). Intrahepatic cholestasis of pregnancy was associated with earlier delivery (p&lt;0.001), lower neonatal birth weight (p&lt;0.001), and higher neonatal intensive care unit admission rates (p=0.007). Within the intrahepatic cholestasis of pregnancy group, maternal fasting bile acid levels inversely correlated with gestational age at delivery (\u03c1=-0.408, p=0.011). Gestational weight gain positively correlated with neonatal birth weight (\u03c1=0.325, p=0.046).  CONCLUSION: Intrahepatic cholestasis of pregnancy is associated with significant maternal nutritional inadequacy and insufficient gestational weight gain. Optimizing maternal nutritional status represents a potentially modifiable pathway for targeted intervention in the comprehensive management of intrahepatic cholestasis of pregnancy.<\/jats:p>","DOI":"10.1590\/1806-9282.20251795","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:36:42Z","timestamp":1781519802000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of maternal nutrition and gestational weight gain on perinatal outcomes in intrahepatic cholestasis of pregnancy"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-8883","authenticated-orcid":false,"given":"Esra","family":"Keles","sequence":"first","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2199-0854","authenticated-orcid":false,"given":"Leyla","family":"Kaya","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1263-142X","authenticated-orcid":false,"given":"Yasemin Tugba","family":"Ogunc","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-2013","authenticated-orcid":false,"given":"Zahide","family":"Kaya","sequence":"additional","affiliation":[{"name":"Uskudar State Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-0406","authenticated-orcid":false,"given":"Kur\u015fad Nuri","family":"Baydili","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-1909","authenticated-orcid":false,"given":"P\u0131nar","family":"Kumru","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41572-025-00633-2","article-title":"Intrahepatic cholestasis of pregnancy","volume":"11","author":"Dajti E","year":"2025","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s40001-022-00802-z","article-title":"Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review","volume":"27","author":"Yang Z","year":"2022","journal-title":"Eur J Med Res"},{"issue":"10174","key":"ref3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(18)31877-4","article-title":"Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses","volume":"393","author":"Ovadia C","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4274\/jcrpe.4930","article-title":"Effect of \u0131ntrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis","volume":"10","author":"Li L","year":"2018","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref5","article-title":"Severe fat-soluble vitamin deficiency suspected secondary to intrahepatic cholestasis of pregnancy: a case report","volume":"35","author":"Sarker M","year":"2022","journal-title":"Case Rep Womens Health"},{"issue":"16","key":"ref6","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.3390\/diagnostics15162002","article-title":"Intrahepatic cholestasis of pregnancy: diagnosis, management, and future directions-a review of the literature","volume":"15","author":"Jasak K","year":"2025","journal-title":"Diagnostics (Basel)"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7762\/cnr.2020.9.3.213","article-title":"Maternal nutrition and \u0131nadequate gestational weight gain in relation to birth weight: results from a prospective cohort study in India","volume":"9","author":"Mishra KG","year":"2020","journal-title":"Clin Nutr Res"},{"key":"ref8","series-title":"A healthy lifestyle - 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