{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:56:17Z","timestamp":1781520977513,"version":"3.54.1"},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"crossref","award":["A2022372"],"award-info":[{"award-number":["A2022372"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The quality of sedation critically affects the success and safety of minor gynecologic surgeries. Ciprofol, a novel analog of propofol, offers rapid onset and recovery with a potentially improved safety profile. This study compared the efficacy and safety of ciprofol and propofol for sedation during minor gynecologic surgery.  METHODS: In this single-center, randomized, double-blind trial, 342 patients scheduled for minor gynecologic procedures were assigned to receive either ciprofol or propofol for anesthesia induction and maintenance. The primary outcomes were anesthesia onset time and surgical success rate. Secondary outcomes included recovery time, hemodynamic stability, body movement, injection pain, satisfaction ratings, and adverse events such as respiratory depression and hypotension.  RESULTS: Both agents achieved a 100% anesthesia success rate, with comparable onset times (ciprofol: 37.2\u00b110.4 s vs. propofol: 38.7\u00b111.2 s; p=0.214). Ciprofol required a fivefold lower total dose (68.5\u00b131.7 mg vs. 359.6\u00b1164.6 mg; p&lt;0.001) and demonstrated superior safety, including fewer body movements (2.4 vs. 15.3%), absence of injection pain (0 vs. 36.5%), and reduced hypotension (10.1 vs. 41.2%; all p&lt;0.001). Satisfaction was higher among surgeons and patients receiving ciprofol.  CONCLUSION: Ciprofol provides anesthesia efficacy equivalent to propofol with significantly enhanced safety and tolerance, supporting its use as a preferred agent for outpatient gynecologic surgery.<\/jats:p>","DOI":"10.1590\/1806-9282.20251801","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:36:33Z","timestamp":1781519793000},"source":"Crossref","is-referenced-by-count":0,"title":["Ciprofol provides safer sedation than propofol in minor gynecologic surgery: evidence from a randomized controlled trial"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0106-9264","authenticated-orcid":false,"given":"Wenbo","family":"Huang","sequence":"first","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4554-9721","authenticated-orcid":false,"given":"Qingtong","family":"Chen","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7809-0241","authenticated-orcid":false,"given":"Dashuo","family":"Peng","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7265-5497","authenticated-orcid":false,"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0197-4968","authenticated-orcid":false,"given":"Wenyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5419-8093","authenticated-orcid":false,"given":"Sijin","family":"Peng","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0012-8792","authenticated-orcid":false,"given":"Guiling","family":"Xie","sequence":"additional","affiliation":[{"name":"Heyuan People's Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bja.2019.02.031","article-title":"Try, try, and try again: personal reflections on the development of propofol","volume":"123","author":"Glen JB","year":"2019","journal-title":"Br J Anaesth"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1021\/acs.jmedchem.7b00254","article-title":"Design, synthesis, and evaluation of novel 2,6-disubstituted phenol derivatives as general anesthetics","volume":"60","author":"Qin L","year":"2017","journal-title":"J Med Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"830791","DOI":"10.3389\/fphar.2022.830791","article-title":"Pharmacodynamics and pharmacokinetics of HSK3486, a novel 2,6-disubstituted phenol derivative as a general anesthetic","volume":"13","author":"Liao J","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s40263-021-00890-1","article-title":"Efficacy and safety of HSK3486 for anesthesia\/sedation in patients undergoing fiberoptic bronchoscopy: a multicenter, double-blind, propofol-controlled, randomized, phase 3 study","volume":"36","author":"Luo Z","year":"2022","journal-title":"CNS Drugs"},{"issue":"5","key":"ref5","first-page":"1607","article-title":"Effects of ciprofol for the induction of general anesthesia in patients scheduled for elective surgery compared to propofol: a phase 3, multicenter, randomized, double-blind, comparative study","volume":"26","author":"Wang X","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12871-024-02479-9","article-title":"Efficacy and safety of ciprofol versus propofol for anesthesia induction in adult patients received elective surgeries: a meta-analysis","volume":"24","author":"Ainiwaer D","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1360508","DOI":"10.3389\/fmed.2024.1360508","article-title":"Efficacy and safety of ciprofol for sedation in outpatient gynecological procedures: a phase III multicenter randomized trial","volume":"11","author":"Xu J","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2147\/DDDT.S414243","article-title":"Efficacy and safety of ciprofol for sedation\/anesthesia in patients undergoing hysteroscopy: a randomized, parallel-group, controlled trial","volume":"17","author":"Lan H","year":"2023","journal-title":"Drug Des Devel Ther"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.dld.2023.09.016","article-title":"Comparison of ciprofol-alfentanil and propofol-alfentanil sedation during bidirectional endoscopy: a prospective, double-blind, randomised, controlled trial","volume":"56","author":"Zhang J","year":"2024","journal-title":"Dig Liver Dis"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000302215&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:36:35Z","timestamp":1781519795000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000302215&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000302215"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20251801","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20251801"}}