{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:51:56Z","timestamp":1781869916185,"version":"3.54.5"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the epidemiological profile of first-trimester pregnant women attending a tertiary reference center in S\u00e3o Paulo, Brazil, and to assess its association with the development of preeclampsia.  METHODS: This study involved retrospective and prospective cohorts of pregnant women undergoing first-trimester ultrasound for aneuploidy screening between 11 and 13+6 weeks\u2019 gestation from 2020 to 2023. Maternal, obstetric, and clinical characteristics, including mean arterial pressure, were collected via questionnaire and clinical measurements. Statistical analyses included descriptive statistics and stepwise forward logistic regression to identify factors associated with preeclampsia development.  RESULTS: A total of 104 pregnant women were included, with a mean age of 30.9 years. Most were White (48.3%), non-smokers (86.5%), overweight (mean body mass index: 28.5 kg\/m2), and had spontaneous pregnancies (100%). Nulliparous and primiparous women accounted for 71.9% of the sample. Low risk for preeclampsia was observed in 84.3% and high risk in 15.7%. History of previous preeclampsia (OR 46.0, 95%CI 3.2\u2013654.2), chronic arterial hypertension (OR 11.2, 95%CI 1.9\u201364.6), and increased first-trimester mean arterial pressure (OR 1.2, 95%CI 1.1\u20131.4) were independently associated with higher preeclampsia risk. Other variables, including race, parity, body mass index, and uterine artery Doppler indices, were not significant predictors.  CONCLUSION: Prior history of preeclampsia, chronic hypertension, and elevated first-trimester mean arterial pressure were key predictors of preeclampsia development. These findings support the importance of first-trimester risk stratification using maternal history and mean arterial pressure measurement to guide early preventive interventions, particularly in settings where biochemical markers are not routinely available.<\/jats:p>","DOI":"10.1590\/1806-9282.20251838","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:02:52Z","timestamp":1781866972000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological profile of pregnant women undergoing first-trimester preeclampsia screening at a tertiary reference center in Brazil"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7149-1093","authenticated-orcid":false,"given":"Vivianne Netto Alves dos","family":"Reis","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil; Universidade Municipal de S\u00e3o Caetano do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3120-1610","authenticated-orcid":false,"given":"Beatriz Bussi","family":"Rosolen","sequence":"additional","affiliation":[{"name":"Universidade Municipal de S\u00e3o Caetano do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-6569","authenticated-orcid":false,"given":"Gustavo Yano","family":"Callado","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-7200","authenticated-orcid":false,"given":"Sandra Rejane Silva","family":"Herbst","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-8932","authenticated-orcid":false,"given":"Ingrid","family":"Schwach","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brazil; Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0550-6411","authenticated-orcid":false,"given":"Carolina Leite","family":"Drummond","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-1161","authenticated-orcid":false,"given":"Giselle Darahem","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"Suppl 1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijgo.12802","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention.","volume":"145","author":"Poon LC","year":"2019","journal-title":"Int J Gynaecol Obstet."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice.","volume":"27","author":"Magee LA","year":"2022","journal-title":"Pregnancy Hypertens"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia.","volume":"9","author":"Dimitriadis E","year":"2023","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/uog.18816","article-title":"ASPRE trial: performance of screening for preterm pre-eclampsia.","volume":"50","author":"Rolnik DL","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ajog.2019.11.1247","article-title":"The competing risk approach for prediction of preeclampsia.","volume":"223","author":"Wright D","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0043-1763495","article-title":"Prediction and prevention of preeclampsia Number 1 \u2013 January 2023.","volume":"45","author":"Peixoto-Filho FM","year":"2023","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1007\/s00404-024-07751-4","article-title":"Evaluation of outcomes and risk factors for recurrent preeclampsia in a subsequent pregnancy.","volume":"310","author":"Nie Q","year":"2024","journal-title":"Arch Gynecol Obstet"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/ajh\/hpae034","article-title":"Does developing interpregnancy hypertension affect the recurrence risk of preeclampsia? 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