{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:55:51Z","timestamp":1781520951803,"version":"3.54.1"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Istanbul University Scientific Research Projects Coordination Unit","award":["TSA-2019-33766"],"award-info":[{"award-number":["TSA-2019-33766"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to compare serum levels of endocan, human epididymis protein 4, sialyl-Tn antigen, and neopterin between women with endometrial cancer and asymptomatic healthy controls, and to explore their discriminatory performance in this case\u2013control setting and clinicopathological associations.  METHODS: Prospective case\u2013control study of 133 women with endometrial cancer and 65 healthy controls. Serum biomarkers were measured before treatment by enzyme-linked immunosorbent assays. Discrimination was evaluated using the area under the receiver operating characteristic curve with optimal cut-offs.  RESULTS: Endocan levels were significantly higher in endometrial cancer patients than in controls (p&lt;0.001), with an area under the curve of 0.758. Serum human epididymis protein 4 was also elevated in patients (p&lt;0.001), with an area under the curve of 0.702. Neopterin and sialyl-Tn did not differ significantly between groups. Endocan and human epididymis protein 4 were higher in women with lymphovascular space invasion (both p&lt;0.05); however, these associations did not remain significant after correction for multiple comparisons.  CONCLUSION: Serum endocan and human epididymis protein 4 were elevated in endometrial cancer patients compared to asymptomatic healthy controls. Neopterin and sialyl-Tn showed no discriminatory value in this setting. Our findings should be interpreted as exploratory and require validation in clinically relevant cohorts.<\/jats:p>","DOI":"10.1590\/1806-9282.20251949","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:37:01Z","timestamp":1781519821000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum human epididymis protein 4, endocan, sialyl-Tn, and neopterin in endometrial cancer: a prospective case\u2013control study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1063-5301","authenticated-orcid":false,"given":"Atahan","family":"Toyran","sequence":"first","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-9318","authenticated-orcid":false,"given":"Yagmur","family":"Minareci","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-1688","authenticated-orcid":false,"given":"Hamdullah","family":"S\u00f6zen","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-5889","authenticated-orcid":false,"given":"Canan","family":"Kucukgergin","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-0833","authenticated-orcid":false,"given":"Abdurrahman Fatih","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-3541","authenticated-orcid":false,"given":"\u0130lknur","family":"Bingul","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4628-8391","authenticated-orcid":false,"given":"Mehmet Guven","family":"Gunver","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4263-237X","authenticated-orcid":false,"given":"Serra Zeynep","family":"Akkoyunlu","sequence":"additional","affiliation":[{"name":"Istanbul University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-0185","authenticated-orcid":false,"given":"Samet","family":"Topuz","sequence":"additional","affiliation":[{"name":"Istanbul 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