{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:43:44Z","timestamp":1782830624868,"version":"3.54.5"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the predictive value of immunonutrition-based indices (Hemoglobin, Albumin, Lymphocyte, Platelet score, prognostic nutritional index, and C-reactive protein\u2013albumin\u2013lymphocyte index) for latency duration and neonatal outcomes in preterm prelabor rupture of membranes.  METHODS: This retrospective cohort study included 145 singleton pregnancies diagnosed with PPROM between 24 and 34 weeks. Patients were categorized by latency duration (\u226448 vs. &gt;48 h), and subgroup analyses used thresholds of 72 h, 96 h, and 7 days. Maternal, laboratory, and neonatal characteristics were compared. Logistic regression adjusted for parity and gestational age evaluated associations between indices and latency.  RESULTS: Hemoglobin, Albumin, Lymphocyte, Platelet, prognostic nutritional index, and C-reactive protein\u2013albumin\u2013lymphocyte values showed no significant differences across latency groups (all p&gt;0.05). Only respiratory distress syndrome was more frequent in the short-latency group (p=0.005).  CONCLUSION: Immunonutrition indices remained stable across latency durations, highlighting the predominance of localized inflammatory and structural mechanisms in preterm prelabor rupture of membranes pathophysiology.<\/jats:p>","DOI":"10.1590\/1806-9282.20251977","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:45:42Z","timestamp":1782827142000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of immunonutrition-based indices (Hemoglobin-Albumin-Lymphocyte-Platelet, prognostic nutritional index, and C-reactive protein\u2013albumin\u2013lymphocyte) with the latency period in preterm prelabor rupture of membranes"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-352X","authenticated-orcid":false,"given":"Ilayda Gercik","family":"Arzik","sequence":"first","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-5537","authenticated-orcid":false,"given":"Hakan","family":"Golbasi","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-4948","authenticated-orcid":false,"given":"Hale Ankara","family":"Aktas","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-2826","authenticated-orcid":false,"given":"Ilknur","family":"Toka","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-8363","authenticated-orcid":false,"given":"Zubeyde Emiralioglu","family":"Cakir","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-6602","authenticated-orcid":false,"given":"Ceren Saglam","family":"Purut","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-7196","authenticated-orcid":false,"given":"Raziye","family":"Torun","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-6805","authenticated-orcid":false,"given":"Emre","family":"Bayram","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-4207","authenticated-orcid":false,"given":"Burak","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey; University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4712-3927","authenticated-orcid":false,"given":"Atalay","family":"Ekin","sequence":"additional","affiliation":[{"name":"Izmir City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","first-page":"178","article-title":"Preterm premature rupture of the membranes","volume":"101","author":"Mercer B","year":"2003","journal-title":"Obstetr Gynecol"},{"issue":"3","key":"ref2","article-title":"Evaluation and management of premature rupture of membranes: a review article","volume":"15","author":"Garg A","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3390\/ijerph18020672","article-title":"Perinatal outcomes associated with latency in late preterm premature rupture of membranes","volume":"18","author":"Choi EK","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/OGX.0000000000000778","article-title":"Antenatal corticosteroids and magnesium sulfate for \u0131mproved preterm neonatal outcomes: a review of guidelines","volume":"75","author":"Tsakiridis I","year":"2020","journal-title":"Obstet Gynecol Surv"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1053\/j.semperi.2017.07.012","article-title":"Preterm prelabor rupture of the membranes: a disease of the fetal membranes","volume":"41","author":"Menon R","year":"2017","journal-title":"Semin Perinatol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/biomedicines13010118","article-title":"The \u0131mpact of amniotic fluid \u0131nterleukin-6, \u0131nterleukin-8, and metalloproteinase-9 on preterm labor: a narrative review","volume":"13","author":"Karampitsakos T","year":"2025","journal-title":"Biomedicines"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12884-018-1780-7","article-title":"Plasma inflammatory and immune proteins as predictors of intra-amniotic infection and spontaneous preterm delivery in women with preterm labor: a retrospective study","volume":"18","author":"Park H","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ajog.2004.12.023","article-title":"High levels of fetal cell-free DNA in maternal serum: a risk factor for spontaneous preterm delivery","volume":"193","author":"Farina A","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/00325481.2024.2359892","article-title":"Predictive value of the HALP score for pre-eclampsia with severe features","volume":"136","author":"Soykan Sert Z","year":"2024","journal-title":"Postgrad Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13048-025-01607-4","article-title":"The impact of preoperative immunonutritional status on prognosis in ovarian cancer: a multicenter real-world study","volume":"18","author":"Liu X","year":"2025","journal-title":"J Ovarian Res"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"2408680","DOI":"10.1080\/01443615.2024.2408680","article-title":"The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers","volume":"44","author":"Esercan A","year":"2024","journal-title":"J Obstet Gynaecol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.2147\/CMAR.S359968","article-title":"Pre-treatment CRP-albumin-lymphocyte \u0131ndex (CALLY Index) as a prognostic biomarker of survival in patients with epithelial ovarian cancer","volume":"14","author":"Wang W","year":"2022","journal-title":"Cancer Manag Res"},{"issue":"2 Pt 1","key":"ref13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0002-9378(99)70212-7","article-title":"Timing of labor induction after premature rupture of membranes between 32 and 36 weeks\u2019 gestation","volume":"180","author":"Neerhof MG","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1471-0528.2006.01028.x","article-title":"Can we improve the diagnosis of rupture of membranes? 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Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000402216&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:45:49Z","timestamp":1782827149000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000402216&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000402216"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20251977","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20251977"}}