{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:55:46Z","timestamp":1781520946836,"version":"3.54.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Postpartum depression is a common mood disorder. Orexin-A, a hypothalamic neuropeptide involved in regulating arousal, stress response, and emotional processes, is implicated in major depressive disorder. The aim of this study was to assess plasma orexin-A levels in women with postpartum depression and to explore its potential biological involvement in postpartum depression.  METHODS: A prospective controlled pilot trial was conducted at two hospitals between April 1, 2024, and June 30, 2025. In total, 60 postpartum women were included: 30 women with postpartum depression, defined as Edinburgh Postpartum Depression Scale \u226513 and confirmed by psychiatric evaluation, and 30 age- and parity-matched healthy controls (Edinburgh Postpartum Depression Scale &lt;13, no psychiatric diagnosis). Venous blood samples were collected 1 month after delivery, and plasma orexin-A was measured. Demographic, obstetric, and clinical characteristics were recorded.  RESULTS: The groups were comparable in terms of demographic and obstetric characteristics. Mean plasma orexin-A levels were significantly lower in women with postpartum depression compared to controls (65.2\u00b110.8 vs. 79.9\u00b16.4 pg\/mL, p=0.021). Orexin-A levels were positively correlated with maternal age (r=0.328, p=0.011) but were not associated with parity, body mass index, neonatal parameters, or family history.  CONCLUSION: This preliminary clinical evidence demonstrates that plasma orexin-A levels are reduced in women with postpartum depression, independent of major demographic or obstetric factors. The findings support orexin-A as a potential biomarker and therapeutic target in postpartum depression. Larger longitudinal studies are needed to confirm causality and investigate orexin-based interventions.<\/jats:p>","DOI":"10.1590\/1806-9282.20252018","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:33:56Z","timestamp":1781519636000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma orexin-A levels in women with postpartum depression: a prospective controlled study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-1336","authenticated-orcid":false,"given":"Mustafa","family":"Kaplanoglu","sequence":"first","affiliation":[{"name":"Medical Park Adana Hospital,  Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-3723","authenticated-orcid":false,"given":"Gulcin","family":"Daglioglu","sequence":"additional","affiliation":[{"name":"Cukurova University,  Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.4088\/JCP.v64n1211","article-title":"The economic burden of depression in the United States: how did it change between 1990 and 2000?","volume":"64","author":"Greenberg PE","year":"2003","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12888-025-06603-y","article-title":"A meta-analysis on the incidence rate of depression in Chinese menopausal women","volume":"25","author":"Li XL","year":"2025","journal-title":"BMC Psychiatry"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.3390\/jcm14124286","article-title":"Postpartum depression: interacting biological pathways and the promising validation of blood-based biomarkers","volume":"14","author":"Ciolac 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L","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.gendis.2020.11.013","article-title":"Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin","volume":"9","author":"Pu C","year":"2020","journal-title":"Genes Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"676336","DOI":"10.3389\/fpsyt.2021.676336","article-title":"Increased hypocretin (orexin) plasma level in depression, bipolar disorder patients","volume":"12","author":"Li H","year":"2021","journal-title":"Front Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/B978-0-444-59489-1.00010-0","article-title":"Orexin receptors as therapeutic drug targets","volume":"198","author":"Gotter AL","year":"2012","journal-title":"Prog Brain Res"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/birt.12785","article-title":"Comparing maternal factors associated with postpartum depression between primiparous adolescents and adults: a large retrospective cohort study","volume":"51","author":"Jeon N","year":"2024","journal-title":"Birth"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s11121-024-01728-0","article-title":"Effectiveness of psychosocial interventions in preventing postpartum depression among teenage mothers-systematic review and meta-analysis of randomized controlled trials","volume":"25","author":"Tenaw LA","year":"2024","journal-title":"Prev Sci"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000402206&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:33:58Z","timestamp":1781519638000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000402206&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000402206"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20252018","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20252018"}}