{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:15:21Z","timestamp":1783682121294,"version":"3.55.0"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to describe the clinical-epidemiological profile and outcome in patients under 15 years of age with differentiated thyroid cancer diagnosed at a state pediatric referral service in Santa Catarina, Brazil, from 2011 to 2020.  METHODS: Retrospective cohort study analyzing the medical records of 16 patients with differentiated thyroid cancer. The variables analyzed were gender, age, year of diagnosis, previous exposure to radiation, personal and family medical history, symptoms\/signs at diagnosis, histological type, staging, therapy, surgical complications, remission rate, and vital status.  RESULTS: Differentiated thyroid cancer occurred in females and adolescents in 62.5% of cases, respectively. Previous radiotherapy was reported in 25% of cases. On physical examination, 56% had a thyroid nodule. Papillary carcinoma was diagnosed in 81.25% of cases. Four patients (25%) were classified as high risk and three never achieving remission. All five low-risk patients and four of the five intermediate-risk patients were in remission. Total thyroidectomy, with or without lymph node resection, was indicated in all cases. Transient hypoparathyroidism occurred in 25%. Radioiodine therapy with I-131 was used in 68.75% of cases, including two low-risk patients treated before 2015. The remission rate was 75%. There were no deaths.  CONCLUSION: Papillary carcinoma is the most common histological type, predominantly in adolescents and females. Previous radiotherapy is a risk factor for differentiated thyroid cancer. The most frequent presentation is a thyroid nodule. Total thyroidectomy is the standard procedure. Radioiodine therapy is not indicated for low-risk patients after 2015. Transient hypoparathyroidism is the most common surgical complication. The remission rate for differentiated thyroid cancer is high.<\/jats:p>","DOI":"10.1590\/1806-9282.20252217","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:42:15Z","timestamp":1783680135000},"source":"Crossref","is-referenced-by-count":0,"title":["Thyroid cancer: experience at a state pediatric referral center"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-5091","authenticated-orcid":false,"given":"Denise Bousfield da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brazil; Universidade do Sul de Santa Catarina,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-2789","authenticated-orcid":false,"given":"Larissa","family":"Cubas","sequence":"additional","affiliation":[{"name":"Family and Community Physician for the Municipal Government,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7389-985X","authenticated-orcid":false,"given":"Jefferson","family":"Traebert","sequence":"additional","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-3893","authenticated-orcid":false,"given":"Marilza Leal","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","series-title":"Pizzo and Poplack's pediatric oncology","first-page":"2078","volume-title":"Endocrine tumors","author":"Mahajan P","year":"2026","edition":"9th ed."},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s12020-020-02378-2","article-title":"Long-term outcome of differentiated thyroid cancer in children and young adults: risk stratification by ATA criteria and assessment of pre-ablation stimulated thyroglobulin as predictors of disease persistence","volume":"70","author":"Karapanou O","year":"2020","journal-title":"Endocrine"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1089\/thy.2014.0460","article-title":"Management guidelines for children with thyroid nodules and differentiated thyroid cancer","volume":"25","author":"Francis GL","year":"2015","journal-title":"Thyroid"},{"issue":"6","key":"ref4","article-title":"End-of-life care: where do cancer patients want to die? A systematic review","volume":"11","author":"Lebbink CA","year":"2022","journal-title":"Asia Pac J Clin Oncol"},{"issue":"3","key":"ref5","first-page":"314","article-title":"Differentiated thyroid cancer in children and adolescents: 12-year experience in a single center","volume":"16","author":"Puga FM","year":"2024","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1111\/jpc.16257","article-title":"Thyroid nodules in children and adolescents: investigation and management","volume":"58","author":"Sandy JL","year":"2022","journal-title":"J Paediatr Child Health"},{"issue":"2","key":"ref7","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin MB","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1210\/jc.2017-02464","article-title":"Diagnostic accuracy of ultrasound with color flow Doppler in children with thyroid nodules","volume":"103","author":"Gannon AW","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.29245\/2767-5157\/2020\/1.1110","article-title":"Thyroid nodules in children and adolescents","volume":"2","author":"Kerr CE","year":"2020","journal-title":"J Endocrinol Sci"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S2213-8587(20)30401-0","article-title":"Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study","volume":"9","author":"Vaccarella S","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"20","key":"ref11","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.3390\/cancers13205104","article-title":"Opposite incidence trends for differentiated and medullary thyroid cancer in young dutch patients over a 30-year time span","volume":"13","author":"Lebbink CA","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/genes10090723","article-title":"Thyroid cancer in the pediatric population","volume":"10","author":"Paulson VA","year":"2019","journal-title":"Genes (Basel)"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20945\/2359-4292-2024-0333","article-title":"Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients","volume":"69","author":"Leite-Almeida L","year":"2025","journal-title":"Arch Endocrinol Metab"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1210\/clinem\/dgab622","article-title":"Age, American Thyroid Association Risk Group, and response to therapy are prognostic factors in children with differentiated thyroid cancer","volume":"107","author":"Redlich A","year":"2022","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000502219&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:42:17Z","timestamp":1783680137000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000502219&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000502219"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20252217","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20252217"}}