{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:24:56Z","timestamp":1786965896980,"version":"build-2736575974"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Polycystic ovary syndrome is one of the most common endocrine disorders of reproductive-aged women worldwide. Phoenixin is a newly identified neuropeptide associated with reproductive functions and energy homeostasis. The aim of this study was to measure the serum levels of phoenixin-14 and phoenixin-20 in women with polycystic ovary syndrome versus controls and to investigate the relationship between phoenixin and polycystic ovary syndrome-related reproductive and metabolic disorders.  METHODS: This study was performed in 36 women with polycystic ovary syndrome and 36 healthy women. The serum levels of phoenixin-14 and phoenixin-20 were measured by using the enzyme-linked immunosorbent assay method.  RESULTS: The serum phoenixin-14, phoenixin-20, luteinizing hormone, insulin levels, and homeostasis model assessment of insulin resistance values were higher in women with polycystic ovary syndrome compared to the control group (p&lt;0.05). In contrast, follicle-stimulating hormone (p&lt;0.01) levels in the polycystic ovary syndrome group were significantly lower than those of the control group, while testosterone levels were significantly higher than those of the controls (p&lt;0.005). A significant positive correlation was found between serum phoenixin-14 and phoenixin-20 (r=0.605; p=0.001), insulin (r=0.458; p=0.012), and homeostasis model assessment of insulin resistance (r=0.453; p=0.014) in polycystic ovary syndrome groups. In polycystic ovary syndrome groups, serum phoenixin-14 was found to have a significant negative correlation with body mass index (r=-0.414; p=0.012). Phoenixin-20 levels correlated negatively with body mass index (r=-0.416; p=0.012) in polycystic ovary syndrome groups.  CONCLUSION: Phoenixin is dysregulated in polycystic ovary syndrome and is associated with metabolic parameters, warranting further mechanistic studies to elucidate its exact role.<\/jats:p>","DOI":"10.1590\/1806-9282.20252301","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:37:40Z","timestamp":1786963060000},"source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted roles of phoenixin in polycystic ovary syndrome: a comparative study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-1029","authenticated-orcid":false,"given":"Sadinaz","family":"Akdu","sequence":"first","affiliation":[{"name":"Fethiye State Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-2924","authenticated-orcid":false,"given":"Ummugulsum","family":"Can","sequence":"additional","affiliation":[{"name":"Konya City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-6441","authenticated-orcid":false,"given":"Osman","family":"Ince","sequence":"additional","affiliation":[{"name":"Fethiye State Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham AE","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref2","series-title":"Fertil Steril","first-page":"19","volume-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"81","year":"2004"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/09513590.2022.2121387","article-title":"Are there new insights for the definition of PCOS?","volume":"38","author":"Baracat EC","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"ref4","first-page":"111","article-title":"Anthropometric, metabolic, and endocrine parameters as predictors of estimated average glucose and other biomarkers of dysglycemia in women with different phenotypes of polycystic ovary syndrome","author":"Medeiros SF","year":"2024","journal-title":"Horm Metab Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-2826.2012.02381.x","article-title":"A novel reproductive peptide, phoenixin","volume":"25","author":"Yosten GL","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroscience.2015.09.055","article-title":"Phoenixin: a candidate pruritogen in the mouse","volume":"310","author":"Cowan A","year":"2015","journal-title":"Neuroscience"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R489","DOI":"10.1152\/ajpregu.00191.2016","article-title":"Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173","volume":"311","author":"Stein LM","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cca.2017.06.013","article-title":"Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome","volume":"471","author":"Ullah K","year":"2017","journal-title":"Clin Chim Acta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bbrc.2020.05.101","article-title":"Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome","volume":"528","author":"Kalamon N","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"ref10","first-page":"3519","article-title":"Serum phoenixin-14 levels of women with polycystic ovary syndrome increase proportionally with BMI","volume":"27","author":"Cundubey CR","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1076800","DOI":"10.3389\/fphar.2023.1076800","article-title":"Current state of phoenixin-the \u0131mplications of the pleiotropic peptide in stress and \u0131ts potential as a therapeutic target","volume":"14","author":"Friedrich T","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews DR","year":"1985","journal-title":"Diabetologia"},{"issue":"s2","key":"ref13","first-page":"60","article-title":"Serum phoenixin-14 and phoenixin-20 levels in women with polycystic ovary syndrome. Oral presentation abstracts","volume":"47","author":"Akdu S","year":"2022","journal-title":"Turkish J Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1038\/s41598-020-63226-x","article-title":"Phoenixin-20 stimulates mRNAs encoding hypothalamo-pituitary-gonadal hormones, is pro-vitellogenic, and promotes oocyte maturation in zebrafish","volume":"10","author":"Rajeswari JJ","year":"2020","journal-title":"Sci Rep"},{"issue":"12","key":"ref15","first-page":"326","article-title":"Influence of phenotypes on the metabolic syndrome of women with polycystic ovary syndrome over a six-year follow-up in Brazil","volume":"11","author":"Soares-Jr JM","year":"2023","journal-title":"Biomedicines"},{"key":"ref16","first-page":"1","article-title":"Polycystic ovary syndrome as a metabolic disease","volume":"21","author":"Helvaci N","year":"2024","journal-title":"Nat Rev Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3390\/metabo11120869","article-title":"Metabolic syndrome and PCOS: pathogenesis and the role of metabolites","volume":"11","author":"Chen W","year":"2021","journal-title":"Metabolites"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"118533","DOI":"10.1016\/j.bbamcr.2019.118533","article-title":"Phoenixin-14 stimulates proliferation and insulin secretion in insulin producing INS-1E cells","volume":"1866","author":"Billert M","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000702217&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:37:43Z","timestamp":1786963063000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000702217&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000702217"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20252301","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20252301"}}