{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:47:06Z","timestamp":1782128826550,"version":"3.54.5"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the use of dienogest in the treatment of deep endometriosis and ovarian endometrioma.  METHODS: This retrospective cohort study included 59 women diagnosed with ovarian endometrioma at a tertiary hospital between 2013 and 2018. Pain scores and endometrioma size were evaluated after 12 months of dienogest use, along with the women's sociodemographic characteristics.  RESULTS: The mean age of the participants was 35.7\u00b16.9 years. Unilateral endometrioma was observed in 38.9% of cases. There was a significant reduction in dysmenorrhea (p=0.011) with dienogest use, but no reduction in other pain symptoms. A reduction in left ovarian volume (p=0.009), mean left endometrioma size (p=0.01), and lesion size in the anterior cul-de-sac (p=0.047) was observed after dienogest treatment. A positive correlation was found between dyschezia and lesions in the posterior cul-de-sac before initiation of dienogest treatment.  CONCLUSION: Dienogest appears to reduce pain in women with deep endometriosis. Our findings support dienogest as an effective therapeutic option.<\/jats:p>","DOI":"10.1590\/1806-9282.20260113","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:48:49Z","timestamp":1782125329000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the use of dienogest in women with deep endometriosis and ovarian endometrioma: a retrospective cohort study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3900-1600","authenticated-orcid":false,"given":"Arissa","family":"Onishi","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-8230","authenticated-orcid":false,"given":"Joao Paulo","family":"Leonardo-Pinto","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-5593","authenticated-orcid":false,"given":"Cristina Laguna","family":"Benetti-Pinto","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-4778","authenticated-orcid":false,"given":"Daniela Angerame","family":"Yela","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"9447","key":"ref1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice LC","year":"2004","journal-title":"Lancet"},{"issue":"238","key":"ref2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejogrb.2019.04.010","article-title":"Dienogest or norethindrone acetate for the treatment of ovarian endometriomas: can we avoid surgery?","volume":"238","author":"Forno S","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/AOG.0000000000005444","article-title":"Medical management of ovarian endometriomas: a systematic review and meta-analysis","volume":"143","author":"Eberle A","year":"2024","journal-title":"Obstet Gynecol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5468\/ogs.2018.61.1.111","article-title":"Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma","volume":"61","author":"Chandra A","year":"2018","journal-title":"Obstet Gynecol Sci"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00404-025-07965-0","article-title":"The effect of endometriosis on oocyte quality: mechanisms, diagnosis and treatment","volume":"311","author":"Fan Y","year":"2025","journal-title":"Arch Gynecol Obstet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"739228","DOI":"10.3389\/fendo.2021.739228","article-title":"Ovarian endometrioma negatively impacts oocyte quality and quantity but not pregnancy outcomes in women undergoing IVF\/ICSI treatment: a retrospective cohort study","volume":"12","author":"Wu Y","year":"2021","journal-title":"Front Endocrinol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"105429","DOI":"10.1016\/j.rbmo.2025.105429","article-title":"Is surgery for endometriomas ever indicated?","volume":"52","author":"Urman B","year":"2026","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315709","article-title":"Conservative endometrioma surgery: the combined technique versus CO2-laser vaporization only (BLAST: Belgium LAser STudy): clinical protocol for a multicenter randomized controlled trial","volume":"20","author":"Bafort C","year":"2025","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejogrb.2025.01.033","article-title":"Clinical effectiveness of progestogens compared to combined oral contraceptive pills in the treatment of endometriosis: a systematic review and meta-analysis","volume":"306","author":"Souza Gaio G","year":"2025","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5653\/cerm.2023.06128","article-title":"Dienogest in endometriosis treatment: a narrative literature review","volume":"50","author":"Lee J","year":"2023","journal-title":"Clin Exp Reprod Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejogrb.2023.12.012","article-title":"The effect of surgery or medication on pain and quality of life in women with endometrioma. 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