{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:06:32Z","timestamp":1784549192679,"version":"3.55.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the comparability of self-collected and clinician-collected samples for human papillomavirus detection, cytological findings, and identification of infectious agents.  METHODS: This prospective controlled clinical trial enrolled 124 women aged 30\u201365 years due for routine cervical cancer screening. This prospective comparative study enrolled 124 women aged 30\u201365 years who were eligible for routine cervical cancer screening. Participants were allocated to either a clinician-collected control group (n=51) or a self-collected group (n=73) via systematic allocation based on clinic registration order. Viral deoxyribonucleic acid analysis was performed by multiplex real-time polymerase chain reaction; cytological evaluation followed the Bethesda classification system. Infectious agents and participant satisfaction were also assessed. Laboratory personnel were blinded to group allocation.  RESULTS: Overall human papillomavirus positivity was 21.8% (27\/124), with rates of 27.5% (14\/51) in the control group and 17.8% (13\/73) in the self-collected group (p=0.200). Cytological abnormalities were detected in 5.5% of self-collected samples (three cases of atypical squamous cells of undetermined significance, one case of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion) versus 0% in the control group (p=0.236). Inflammatory smear findings, Candida (9.8 vs. 8.2%), and Trichomonas vaginalis (0 vs. 1.4%) detection rates were similar between groups. Mean satisfaction score was 12.6\u00b11.62 out of 16 (78.8% positive responses).  CONCLUSION: Self-collected human papillomavirus sampling yields results diagnostically comparable to clinician-collected specimens. Self collected human papillomavirus sampling demonstrated similar human papillomavirus detection rates compared with clinician-collected specimens. Given its feasibility and high acceptability, self-collection may serve as an effective complementary approach in cervical cancer screening programs, particularly for reaching women who have not previously participated in screening.<\/jats:p>","DOI":"10.1590\/1806-9282.20260122","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:27:49Z","timestamp":1784546869000},"source":"Crossref","is-referenced-by-count":0,"title":["Self-collected versus clinician-collected human papillomavirus samples"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-3718","authenticated-orcid":false,"given":"Ramazan","family":"B\u00fclb\u00fc","sequence":"first","affiliation":[{"name":"Aksaray Training and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-7126","authenticated-orcid":false,"given":"Jule Eri\u00e7","family":"Horasanl\u0131","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-4134","authenticated-orcid":false,"given":"Arif Caner","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Ali Kemal Belviranl\u0131 Obstetrics and Gynecology and Children's Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-9165","authenticated-orcid":false,"given":"Fatih","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"K\u00fctahya City Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1136\/ijgc-2024-005579","article-title":"Cervical cancer: a new era","volume":"34","author":"Caruso G","year":"2024","journal-title":"Int J Gynecol Cancer"},{"issue":"20","key":"ref2","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMsr2030640","article-title":"The IARC perspective on cervical cancer screening","volume":"385","author":"Bouvard V","year":"2021","journal-title":"N Engl J Med"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2020-003743","article-title":"HPV self-sampling for cervical cancer screening: a systematic review of values and preferences","volume":"6","author":"Nishimura H","year":"2021","journal-title":"BMJ Glob Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"106900","DOI":"10.1016\/j.ypmed.2021.106900","article-title":"Worldwide use of HPV self-sampling for cervical cancer screening","volume":"154","author":"Serrano B","year":"2022","journal-title":"Prev Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ypmed.2018.08.034","article-title":"Factors associated with human papillomavirus (HPV) test acceptability in primary screening for cervical cancer: a mixed methods research synthesis","volume":"116","author":"Tatar O","year":"2018","journal-title":"Prev Med"},{"key":"ref6","series-title":"National standards for cervical cancer screening program","year":"2013"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1186\/s12889-019-7292-1","article-title":"Age-related acceptability of vaginal self-sampling in cervical cancer screening at two university hospitals: a pilot cross-sectional study","volume":"19","author":"Lorenzi NPC","year":"2019","journal-title":"BMC Public Health"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.283.1.81","article-title":"HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer","volume":"283","author":"Wright TC","year":"2000","journal-title":"JAMA"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ygyno.2007.01.023","article-title":"Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis","volume":"105","author":"Petignat P","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1186\/s12889-024-19881-0","article-title":"Invitation strategy of vaginal HPV self-sampling to improve participation in cervical cancer screening: a systematic review and meta-analysis of randomized trials","volume":"24","author":"Wong HY","year":"2024","journal-title":"BMC Public Health"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"100898","DOI":"10.1016\/j.clinsp.2026.100898","article-title":"Self-collected versus clinician-collected samples for HPV testing: a meta-analysis revealing lower sensitivity for detecting high-grade cervical lesions","volume":"81","author":"Lima GGS","year":"2026","journal-title":"Clinics (Sao Paulo)"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1158\/1055-9965.EPI-25-0362","article-title":"Accuracy of HPV self-collection compared with clinician-collected HPV testing and cytology: a meta-analysis","volume":"34","author":"Phillips SA","year":"2025","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.11081","article-title":"Clinical validation of a vaginal cervical cancer screening self-collection method for at-home use: a nonrandomized clinical trial","volume":"8","author":"Fitzpatrick MB","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cncy.22498","article-title":"A positive HPV test with positive p16\/Ki-67 double staining in self-sampled vaginal material is an accurate tool to detect women at risk for cervical cancer","volume":"130","author":"Lorenzi NPC","year":"2022","journal-title":"Cancer Cytopathol"},{"key":"ref15","article-title":"Lessons learned from comparing self-collected vs. physician-collected vaginal swabs for diagnosing infections in resource-limited settings: a 24-year review","volume":"36","author":"Lachyan DA","year":"2024","journal-title":"Braz J Sex Transm Dis"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000602201&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:27:52Z","timestamp":1784546872000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000602201&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000602201"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20260122","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20260122"}}