{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:52:45Z","timestamp":1792151565616,"version":"4.4.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Fibrosis-4 (a liver fibrosis index) and triglyceride\u2013glucose (an insulin resistance surrogate) indices may be markers associated with kidney stone risk. The aim of this study was to evaluate the association between triglyceride\u2013glucose and fibrosis-4 indices and the presence of nephrolithiasis in adults.  METHODS: This retrospective cross-sectional case\u2013control study included 918 adults (785 with nephrolithiasis, 133 controls) evaluated between January 2016 and December 2023. Controls were consecutive patients from the same urology outpatient population who underwent abdominal imaging for non-stone-related urological indications, with no radiological evidence of nephrolithiasis. Triglyceride\u2013glucose and fibrosis-4 indices were calculated using standard formulas. The triglyceride\u2013glucose index was standardized (per 1 SD=0.23 units) prior to multivariable logistic regression including age, sex, and fibrosis-4.  RESULTS: Triglyceride\u2013glucose was significantly higher in stone formers (4.87\u00b10.21 vs. 4.64\u00b10.20; p&lt;0.001). In multivariable analysis, triglyceride\u2013glucose independently predicted nephrolithiasis (adjusted OR per 1 SD=3.52; 95%CI 2.48\u20135.00; p&lt;0.001); male sex was also independently associated. Fibrosis-4 was not independently associated (p=0.809). Triglyceride\u2013glucose area under the curve was 0.779 (95%CI 0.729\u20130.827), consistent across both sexes (interaction p=0.135).  CONCLUSION: Each 1 SD increase in triglyceride\u2013glucose was associated with a 3.5-fold increase in odds of nephrolithiasis, independent of age, sex, and fibrosis-4. Fibrosis-4 showed no independent utility. Prospective studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1590\/1806-9282.20260298","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:15:53Z","timestamp":1792149353000},"source":"Crossref","is-referenced-by-count":0,"title":["Association between triglyceride\u2013glucose and fibrosis-4 indices and nephrolithiasis: a cross-sectional case\u2013control study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-7827","authenticated-orcid":false,"given":"Sezin Do\u011fan","family":"\u00c7ak\u0131r","sequence":"first","affiliation":[{"name":"University of Health Sciences","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-2873","authenticated-orcid":false,"given":"Mustafa","family":"Erko\u00e7","sequence":"additional","affiliation":[{"name":"University of Health Sciences","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-6581","authenticated-orcid":false,"given":"Mine","family":"Ada\u015f","sequence":"additional","affiliation":[{"name":"University of Health Sciences","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1590\/2175-8239-jbn-2024-0189en","article-title":"Brazilian Guidelines on evaluation and clinical management of nephrolithiasis: Brazilian Society of Nephrology","volume":"47","author":"Carvalho M","year":"2025","journal-title":"J Bras Nefrol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5489\/cuaj.7872","article-title":"UPDATE - Canadian Urological Association guideline: evaluation and medical management of kidney stones","volume":"16","author":"Bhojani N","year":"2022","journal-title":"Can Urol Assoc J"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1210\/jc.2011-3492","article-title":"Clinical review. 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