{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:05:04Z","timestamp":1789995904887,"version":"4.0.1"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The objective of this study is to evaluate the effects of bromelain on serum endocannabinoid levels and oxidative stress markers in a rat model of surgically induced endometriosis.  METHODS: A total of 24 female Wistar albino rats were randomly assigned to three groups (n=8 each): Sham, endometriosis, and endometriosis treated with bromelain (endometriosis+B). Endometriosis was induced by autotransplantation of uterine tissue. Bromelain (20 mg\/kg\/day) was administered orally for 15 consecutive days. Serum levels of 2-arachidonoylglycerol, anandamide, superoxide dismutase, glutathione, and malondialdehyde were measured using ELISA. Statistical analysis was performed using one-way analysis of variance followed by Tukey's post hoc test.  RESULTS: Induction of endometriosis significantly reduced serum 2-arachidonoylglycerol, anandamide, superoxide dismutase, and glutathione levels while increasing malondialdehyde concentrations compared with the Sham group (p&lt;0.05). Bromelain treatment significantly improved most endocannabinoid and oxidative stress parameters compared with the untreated endometriosis group (p&lt;0.05).  CONCLUSION: Bromelain ameliorated endocannabinoid deficiency and oxidative stress in experimental endometriosis. These findings suggest that bromelain may represent a promising non-hormonal therapeutic candidate targeting interconnected inflammatory and redox pathways in endometriosis.<\/jats:p>","DOI":"10.1590\/1806-9282.20260396","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:19:20Z","timestamp":1789993160000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of bromelain on endocannabinoid system and oxidative stress in a rat model of endometriosis"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-4229","authenticated-orcid":false,"given":"Irem","family":"Herguner","sequence":"first","affiliation":[{"name":"Sincan Training and Research Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-1444","authenticated-orcid":false,"given":"Taylan","family":"Onat","sequence":"additional","affiliation":[{"name":"Sincan Training and Research Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-2693","authenticated-orcid":false,"given":"Emin","family":"Kaymak","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7601-7015","authenticated-orcid":false,"given":"Zeliha Nur","family":"Erg\u00fcl","sequence":"additional","affiliation":[{"name":"Sincan Training and Research Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-3515","authenticated-orcid":false,"given":"Seyma","family":"Fadiloglu","sequence":"additional","affiliation":[{"name":"Sincan Training and Research Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.3390\/ijms221910554","article-title":"Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature)","volume":"22","author":"Smolarz B","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"ref2","first-page":"194","article-title":"Endometriosis. 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