{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:16:31Z","timestamp":1787926591656,"version":"build-2784847793"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Unit of Health Sciences University, Istanbul","award":["2025\/033"],"award-info":[{"award-number":["2025\/033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: This case-control study aims to investigate the relationship between low pregnancy-associated plasma protein-A levels and serum urotensin-II concentrations between the 11th and 14th weeks of pregnancy.  METHODS: This study was conducted between October 2024 and October 2025 at the perinatology outpatient clinic of a Training and Research Hospital in Istanbul. A total of 84 women were consecutively included and divided into case and control groups based on pregnancy-associated plasma protein-A results. Written consent and a descriptive form were obtained. Combined screening tests were performed, and blood samples were collected for urotensin-II measurement.  RESULTS: No significant difference was observed between the case and control groups in terms of urotensin-II concentration. A statistically significant positive correlation was found between pregnancy-associated plasma protein-A levels and urotensin-II concentrations. Each 1 mIU\/mL increase in pregnancy-associated plasma protein-A concentration was associated with an approximate 36.45 ng\/mL increase in urotensin-II concentration.  CONCLUSION: In this study, no significant association was demonstrated between pregnancy-associated plasma protein-A levels and urotensin-II levels in case and control groups; however, a correlation was identified between pregnancy-associated plasma protein-A levels and urotensin-II concentrations.<\/jats:p>","DOI":"10.1590\/1806-9282.20260478","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:16:24Z","timestamp":1787922984000},"source":"Crossref","is-referenced-by-count":0,"title":["Low pregnancy-associated plasma protein-A and serum urotensin-II in 11\u201314 weeks gestation: case-control study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8449-2387","authenticated-orcid":false,"given":"Yusa Irfan","family":"Yildirim","sequence":"first","affiliation":[{"name":"Antalya Kepez State Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-5558","authenticated-orcid":false,"given":"Rojda Bayar","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Antalya Kepez State Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-375X","authenticated-orcid":false,"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Hamidiye University of Health Sciences,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ghir.2006.11.003","article-title":"Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs","volume":"17","author":"Boldt HB","year":"2007","journal-title":"Growth Horm 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