{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:35:36Z","timestamp":1787924136129,"version":"build-2784847793"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to assess the effects of preexisting hypothyroidism on the course of coronavirus disease 2019 and on delivery and fetal outcomes in pregnant women with coronavirus disease 2019.  METHODS: Two groups of pregnant women with coronavirus disease 2019 were included, that is, those with no comorbid condition and those with preexisting hypothyroidism as the sole comorbid condition. We assessed the course of coronavirus disease 2019 and delivery and fetal outcomes in the two groups.  RESULTS: Of 167 participants, 143 had no preexisting comorbidity, and 24 had hypothyroidism as the sole comorbid condition. Patients with hypothyroidism had significantly higher incidences of severe coronavirus disease 2019 and the following coronavirus disease 2019 symptoms: shortness of breath, loss of sense of smell and\/or taste, and tachypnea. Hospital (length of stay, intensive care unit admission and stay, mortality), delivery (normal vaginal delivery, cesarean section, and emergency cesarean section), and fetal (preterm, birth weight, 1- and 5-min Appearance, Pulse, Grimace, Activity, and Respiration scores, stillbirth) outcomes were similar in the two groups. The outcomes were also similar in patients with severe coronavirus disease 2019, though those with hypothyroidism had shorter hospital stay and intensive care unit stay and lower rates of intensive care unit admission, mortality, emergency cesarean section, preterm delivery, and low birth weight newborns.  CONCLUSION: Our results suggest that preexisting hypothyroidism has adverse impacts on the severity of coronavirus disease 2019 and its symptoms. Considering severe coronavirus disease 2019 cases, seemingly favorable hospital, delivery, and fetal outcomes on the part of hypothyroidism may be worth further research.<\/jats:p>","DOI":"10.1590\/1806-9282.20260677","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:15:45Z","timestamp":1787922945000},"source":"Crossref","is-referenced-by-count":0,"title":["Impacts of hypothyroidism on clinical, delivery, and fetal outcomes of coronavirus disease 2019: a cross-sectional study"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-3363","authenticated-orcid":false,"given":"Suzan","family":"\u015eahin","sequence":"first","affiliation":[{"name":"Kartal Dr. L\u00fctfi K\u0131rdar City Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-5868","authenticated-orcid":false,"given":"B\u00fclent","family":"Kaya","sequence":"additional","affiliation":[{"name":"Kartal Dr. L\u00fctfi K\u0131rdar City Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-543X","authenticated-orcid":false,"given":"Emre","family":"Mat","sequence":"additional","affiliation":[{"name":"Kartal Dr. L\u00fctfi K\u0131rdar City Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-009X","authenticated-orcid":false,"given":"Gazi","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Kartal Dr. L\u00fctfi K\u0131rdar City Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-1612","authenticated-orcid":false,"given":"Naile","family":"G\u00f6kkaya","sequence":"additional","affiliation":[{"name":"Kartal Dr. L\u00fctfi K\u0131rdar City Hospital,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-0474","authenticated-orcid":false,"given":"Adil","family":"Barut","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa,  T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/MED.0000000000000654","article-title":"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and thyroid disease. An update.","volume":"28","author":"Brix TH","year":"2021","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41574-023-00946-w","article-title":"Thyroid dysfunction in COVID-19.","volume":"20","author":"Lui DTW","year":"2024","journal-title":"Nat Rev Endocrinol."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"708333","DOI":"10.3389\/fendo.2021.708333","article-title":"Coronavirus disease 2019 and the thyroid - progress and perspectives.","volume":"12","author":"Inaba H","year":"2021","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"bqab004","DOI":"10.1210\/endocr\/bqab004","article-title":"Potential interaction between SARS-CoV-2 and thyroid: a review.","volume":"162","author":"Chen W","year":"2021","journal-title":"Endocrinology."},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1089\/thy.2020.0363","article-title":"Thyroid function analysis in 50 patients with COVID-19: a retrospective study.","volume":"31","author":"Chen M","year":"2021","journal-title":"Thyroid."},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"e926","DOI":"10.1210\/clinem\/dgaa813","article-title":"Thyroid dysfunction in relation to immune profile, disease status, and outcome in 191 patients with COVID-19.","volume":"106","author":"Lui DTW","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"ref7","series-title":"Management considerations for pregnant patients with COVID-19.","year":"2021"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1515\/jpm-2022-0564","article-title":"Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience.","volume":"51","author":"Sinaci S","year":"2023","journal-title":"J Perinat Med."},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/jpm-2023-0280","article-title":"Pregnancy and neonatal outcomes of SARS-CoV-2 infection discovered at the time of delivery: a tertiary center experience in North Italy.","volume":"52","author":"Libretti A","year":"2023","journal-title":"J Perinat Med."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"05018","DOI":"10.7189\/jogh.11.05018","article-title":"A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity.","volume":"11","author":"Lassi ZS","year":"2021","journal-title":"J Glob Health."},{"key":"ref11","article-title":"Hypothyroidism in pregnancy.","author":"Okosieme OE","year":"2000","journal-title":"Endotex."},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cen.13329","article-title":"Preconception TSH and pregnancy outcomes: a population-based cohort study in 184 611 women.","volume":"86","author":"Chen S","year":"2017","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"e20240842","DOI":"10.1590\/1806-9282.20240842","article-title":"Pregnancy and delivery outcomes in coronavirus disease 2019: a cross-sectional study from a tertiary center.","volume":"71","author":"\u015eahin S","year":"2025","journal-title":"Rev Assoc Med Bras (1992)."},{"issue":"5","key":"ref14","first-page":"e61206","article-title":"SARS-CoV-2 infection in pregnant women with hypothyroidism.","volume":"16","author":"Iordache MD","year":"2024","journal-title":"Cureus."}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302026000802213&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:15:48Z","timestamp":1787922948000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302026000802213&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0104-42302026000802213"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20260677","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20260677"}}