{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:02:56Z","timestamp":1791198176575,"version":"4.1.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to evaluate the predictive value of systemic inflammation markers for abnormal cervical screening results and high-grade cervical lesions in women participating in a human papillomavirus- and cytology-based screening program, thereby determining colposcopy indications more accurately to reduce unnecessary colposcopy requests and prevent overtreatment.  METHODS: A total of 2,758 women who underwent cervical cancer screening between 2020 and 2025 were included in this retrospective cross-sectional study. Abnormal screening results were defined as abnormal cytology (\u2265Atypical squamous cells of undetermined significance [ASC-US]) and\/or high-risk human papillomavirus positivity. Hematological parameters measured within 1 month prior to screening were used to calculate neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index. Continuous variables were evaluated using nonparametric tests, and the independent predictors of abnormal screening results and high-grade lesions were identified using logistic regression models.  RESULTS: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index values were significantly higher in the abnormal smear groups and in human papillomavirus -positive patients (all p&lt;0.001). Neutrophil-to-lymphocyte ratio displayed the highest diagnostic performance for high-grade lesions (area under the curve=0.871; cutoff value &gt;4.41, sensitivity 66.7%, specificity 99.2%), followed by systemic immune-inflammation index (area under the curve=0.847), while platelet-to-lymphocyte ratio showed lower specificity (area under the curve=0.741).  CONCLUSION: In conclusion, our findings suggest that inflammatory markers are associated with abnormal cervical screening results. To determine the significance and clinical utility of serum inflammatory markers, multicenter clinical trials involving larger patient cohorts are needed.<\/jats:p>","DOI":"10.1590\/1806-9282.20260706","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:40:36Z","timestamp":1791196836000},"source":"Crossref","is-referenced-by-count":0,"title":["Retrospective study of inflammatory markers in high-grade cervical lesions"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0747-4990","authenticated-orcid":false,"given":"P\u0131nar","family":"Y\u0131ld\u0131z","sequence":"first","affiliation":[{"name":"Academic Hospital","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-6356","authenticated-orcid":false,"given":"G\u00fcne\u015f","family":"Top\u00e7u","sequence":"additional","affiliation":[{"name":"Bah\u00e7elievler Medipol University Hospital","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-3675","authenticated-orcid":false,"given":"Ger\u00e7ek","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Istanbul Health and Technology University","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-6643","authenticated-orcid":false,"given":"Asiye","family":"Uzun","sequence":"additional","affiliation":[{"name":"Bah\u00e7elievler Medipol University Hospital","place":["Istanbul, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12905-025-03733-z","article-title":"Cervical cancer screening: a comparative study of TruScreen vs. Pap smear.","volume":"25","author":"Alhudhud M","year":"2025","journal-title":"BMC Womens Health."},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide.","volume":"156","author":"Filho AM","year":"2025","journal-title":"Int J Cancer."},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.30621\/jbachs.1775019","article-title":"Serum inflammatory biomarkers to discriminate the cervical squamous intraepithelial lesions.","volume":"10","author":"\u0130lgen O","year":"2026","journal-title":"J Basic Clin Health Sci."},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3390\/diagnostics13040610","article-title":"Prevention strategies and early diagnosis of cervical cancer: current state and prospects.","volume":"13","author":"Kakotkin VV","year":"2023","journal-title":"Diagnostics (Basel)."},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00404-018-4953-8","article-title":"Accuracy of colposcopy-directed biopsy in detecting early cervical neoplasia: a retrospective study.","volume":"299","author":"Stuebs FA","year":"2019","journal-title":"Arch Gynecol Obstet."},{"issue":"2","key":"ref6","first-page":"229","article-title":"A review of cervical cancer: incidence and disparities.","volume":"112","author":"Buskwofie A","year":"2020","journal-title":"J Natl Med Assoc."},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/21645515.2020.1805993","article-title":"Prevalence and genotype distribution of human papillomavirus among women with cervical lesions in Shenzhen city, China.","volume":"17","author":"Mai Q","year":"2021","journal-title":"Hum Vaccin Immunother."},{"key":"ref8","article-title":"Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters.","volume":"15","author":"Sun C","year":"2025","journal-title":"Front Oncol."},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.7150\/jca.56170","article-title":"Systemic inflammatory score predicts overall survival in patients with cervical cancer.","volume":"12","author":"Xu M","year":"2021","journal-title":"J Cancer."},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12957-020-01974-w","article-title":"Prognostic prediction of systemic immune-inflammation index for patients with gynecological and breast cancers: a meta-analysis.","volume":"18","author":"Ji Y","year":"2020","journal-title":"World J Surg Oncol."},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12893-021-01180-9","article-title":"Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative 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Cancer."},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"e16278","DOI":"10.1111\/jog.16278","article-title":"The role of serum inflammatory markers in determining the severity of cervical lesions.","volume":"51","author":"Atl\u0131han U","year":"2025","journal-title":"J Obstet Gynaecol Res."},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"e143466","DOI":"10.5812\/ijcm-143466","article-title":"Predictive value of pretreatment hematological parameters for response to definitive chemoradiotherapy in locally advanced cervical cancer: a prospective study.","volume":"17","author":"Novin K","year":"2024","journal-title":"Int J Cancer Manag."}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica 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