{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:31:52Z","timestamp":1782970312130,"version":"3.54.5"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Objective The aim of this cross-sectional study was to evaluate the prevalence of low bone mass density in cystic fibrosis patients as well as to evaluate the factors associated with bone mass in such patients. Methods Bone mass density was measured by dual-photon X-ray absorptiometry of lumbar spine (L1-L4), in patients \u226419 years old, or lumbar spine and femur (total and neck) in patients \u226520 years old. Evaluations of nutritional status, biochemical parameters, and lung function were performed. Medication data were obtained from medical records. Results Fifty-eight patients were included in the study (25 males\/ 33 females), mean age 23.9 years (16-53years). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in cystic fibrosis patients correlated positively with body mass index (r= 0.3, p=0.001), and forced expiratory volume in the first second (% predicted) (r=0.415, p=0.022). Mean lumbar spine Z-score was higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with no hospitalization in the last 3 months (p=0.02). After multivariate analysis, body mass index (p= 0.001) and sex (p=0.001) were independently associated with Z-score in lumbar spine. Conclusion Low bone mass is a frequent problem in patients with CF, being independently associated with body mass index, and male sex.<\/jats:p>","DOI":"10.1590\/1806-9282.60.01.012","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T15:04:49Z","timestamp":1402671889000},"page":"53-58","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis"],"prefix":"10.1590","volume":"60","author":[{"given":"Roberta","family":"Vanacor","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana V.","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia A.","family":"Marcondes","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P.","family":"Corte","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline M.","family":"Ascoli","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Z. de","family":"Azambuja","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Scopel","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia V. dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo T. R.","family":"Dalcin","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A. M.","family":"Faulhaber","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia W.","family":"Furlanetto","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jcf.2009.04.001","article-title":"An overview of international literature from cystic fibrosis registries: 1. 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impact of the use of glucocorticoids on the estimate by FRAX<sup>\u00ae<\/sup> of the 10 year risk of fracture from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX<sup>\u00ae<\/sup>","volume":"14","author":"Leib ES","year":"2011","journal-title":"J Clin Densitom"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica 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