{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:08:25Z","timestamp":1695730105232},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Objective: this study aimed to report the allele and haplotype frequencies of volunteer bone marrow donors (VBMD) from the state of Rio Grande do Norte (RN) who were enrolled in the Brazilian Volunteer Bone Marrow Donor Registry (REDOME). Methods: the sample comprised 12,973 VBMD who had their allele and haplotype frequencies calculated by Arlequin 3.5.1.2. A multivariate analysis of the data was obtained through a principal component analysis (PCA) and hierarchical cluster analysis (HCA) performed with SPSS 8.0. Results: the most frequent allelic group was HLA-A*02, followed by -DRB1*13, -DRB1*04, -DRB1*07, -B*44, -B*35, -A*24 and -DRB1*01. Of the 2,701 haplotypes observed, the three most frequent were HLA-A*01 B*08 DRB1*03 (1.62%), -A*29 B*44 DRB1*07 (1.56%) and -A*02 B*44 DRB1*04 (1.29%). These haplotypes were in linkage disequilibrium. RN allele and haplotype frequencies were very similar to those in other Brazilian states in which similar studies have been performed. The PCA revealed that RN is highly genetically similar to Caucasian populations, especially those from Iberian countries, which strongly influenced the state\u2019s ethnic composition. Africans and Amerindians also influenced the RN population structure, to a lesser extent. Conclusion: the HCA reinforced the conclusion that, despite its highly admixed profile, the RN population is genetically similar to European and European-descended populations. The PCA also showed that RN cities do not contribute to the same extent to REDOME, with less populous cities being underrepresented, indicating the need to enroll more VBMD from these smaller cities to faithfully depict the state\u2019s population structure in the database.<\/jats:p>","DOI":"10.1590\/1806-9282.61.01.023","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T21:39:21Z","timestamp":1429220361000},"page":"23-29","source":"Crossref","is-referenced-by-count":3,"title":["Rio Grande do Norte, Brazil, voluntary bone marrow donors registry analysis"],"prefix":"10.1590","volume":"61","author":[{"given":"Marina Barguil","family":"Mac\u00eado","sequence":"first","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Tamie","family":"Tsuneto","sequence":"additional","affiliation":[{"name":"Federal University of Maring\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary Almeida de Oliveira","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Dalton Cunha Blood Center, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Socorro Belarmino de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Dalton Cunha Blood Center, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Machado","family":"Moita Neto","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto Socorro da","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Cl\u00e1udio Demes da Mata","family":"Sousa","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marayza Gomes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herton Luiz Alves","family":"Sales","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Renato Pereira de Moura","family":"Barroso","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anaregina de Sousa","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semiramis Jamil Hadad do","family":"Monte","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, 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