{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T02:16:43Z","timestamp":1648952203164},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p> Introduction: valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient\u2019s inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. Objective: to report a series of cases of valve replacement, using a bioprosthetic or mechanical valve, and the inflammatory profile of them. Methods: patients older than 18 years and with bioprosthetic or mechanical valve placed for a minimum of 6 months and maximum of 2 years were included. In addition to the demographic characteristics of each patient, inflammatory markers were measured and a comparison was made of echocardiographic results before (based on medical records) and after surgery. A total of 46 patients were enrolled, 23 with mechanical valve and 23 with bioprosthetic valve. Results: of the 46 patients, 20 presented complete data were included, 12 with bioprosthetic and 8 with mechanical valve. There was no difference between types of prosthesis or implant site for the values of inflammatory markers although they were all above reference range. Discussion: patients undergoing aortic mechanical valve implant benefited more than those undergoing bioprosthetic implant and both with much better results than those of valve replacements performed on mitral valve. In short, there was no difference in relation to inflammatory biomarkers.<\/jats:p>","DOI":"10.1590\/1806-9282.61.01.058","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T21:39:57Z","timestamp":1429220397000},"page":"58-60","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement"],"prefix":"10.1590","volume":"61","author":[{"given":"Marcelo Rodrigues","family":"Bacci","sequence":"first","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neif","family":"Murad","sequence":"additional","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Roberto","family":"Breda","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Voltareli Cesar de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Herszkowics","sequence":"additional","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalia Kitamoto","family":"Cardoso","sequence":"additional","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Luiz Affonso","family":"Fonseca","sequence":"additional","affiliation":[{"name":"FMABC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"9B","key":"ref1","doi-asserted-by":"crossref","first-page":"3J","DOI":"10.1016\/S0002-9149(97)00831-X","article-title":"An epidemiologic perspective of systemic hypertension, ischemic heart disease and heart failure","volume":"80","author":"Wilson PW","year":"1997","journal-title":"Am J Cardiol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.105.171600","article-title":"Heart disease and stroke statistics 2006 update: a report from the American Heart Association Statistical Committee and Stroke Statistics","volume":"113","author":"Thom T","year":"2006","journal-title":"Circulation"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1136\/hrt.2003.013102","article-title":"Comparison of outcomes after aortic valve replacement with a mechanical valve or a bioprosthesis using microsimulation","volume":"90","author":"Puvimanasinghe JP","year":"2004","journal-title":"Heart"},{"key":"ref4","first-page":"5","article-title":"Time Course of C-Reactive Protein, Tumour Necrosis Factor-Alpha and Monocyte Chemoattractant Protein-1 Following the Surgical Treatment of Patients with Aortic Valve Stenosis","volume":"48","author":"Kastellanos SS","year":"2007","journal-title":"Hellenic J 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Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v61n1\/0104-4230-ramb-61-01-0058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T02:55:32Z","timestamp":1495508132000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302015000100016&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0104-42302015000100016"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.61.01.058","relation":{},"ISSN":["0104-4230"],"issn-type":[{"value":"0104-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}