{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:11:02Z","timestamp":1748491862538,"version":"3.41.0"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Summary Objective: to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series. Methods: sociodemographic and clinical data were collected from patients, and a systematic literature review performed, focusing on national studies on the clinical profile of MG patients. Results: sixty nine patients were enrolled in the study. Fifty five (91%) subjects were female and the mean age (SD) was 37.6 (\u00b111.4) years. The mean disease duration was 14.1 years. Regarding treatment, prednisone was the most used strategy (64%), followed by the use of azathioprine (43%). There was no difference between thymectomized (42) and non-thymectomized (27) patients regarding disease severity and medication use. Conclusion: clinical and socio-demographic features of this MG sample from a University-based clinic resemble those reported in other Brazilian series and in the international literature.<\/jats:p>","DOI":"10.1590\/1806-9282.61.02.156","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T22:53:48Z","timestamp":1434581628000},"page":"156-160","source":"Crossref","is-referenced-by-count":1,"title":["Clinical profile of patients with myasthenia gravis followed at the University Hospital, Federal University of Minas Gerais"],"prefix":"10.1590","volume":"61","author":[{"given":"Aline Mansueto","family":"Mour\u00e3o","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz S\u00e9rgio Mageste","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Regina","family":"Comini-Frota","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise da Silva","family":"Freitas","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted M.","family":"Burns","sequence":"additional","affiliation":[{"name":"University of Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stela Maris Aguiar","family":"Lemos","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","article-title":"Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity","volume":"8","author":"Meriggioli MN","year":"2009","journal-title":"Lancet Neurol"},{"issue":"25","key":"ref2","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman DB","year":"1994","journal-title":"N Engl J Med"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mus.20950","article-title":"Lifetime course of myasthenia gravis","volume":"37","author":"Grob D","year":"2008","journal-title":"Muscle Nerve"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1001\/archneur.1991.00530190081019","article-title":"Epidemiology of myasthenia gravis in Denmark. 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