{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:06Z","timestamp":1787023086346,"version":"build-2736575974"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Summary The pineal gland is responsible for producing a hormone called melatonin (MEL), and is accepted as the gland that regulates reproduction in mammals. Prolactin (PRL) also exhibits reproductive activity in animals in response to photoperiod. It is known that the concentrations of PRL are high in the summer and reduced during winter, the opposite of what is seen with melatonin in these seasons. In placental mammals, both prolactin and melatonin affect implantation, which is considered a critical point of pregnancy, since a successful pregnancy requires the development of a synchronous interaction between the endometrium and blastocyst for placental development. It is also known that PRL levels during pregnancy are essential for the maintenance of pregnancy, because this hormone induces the corpus luteum to produce progesterone, in addition to stimulating blastocyst implantation to maintain pregnancy and form the placenta. However, melatonin levels in plasma have also been shown to increase during pregnancy, peaking at the end of this period, which suggests that this hormone plays an important role in the maintenance of pregnancy. Thus, it is clear that treatment with prolactin or melatonin interferes with the processes responsible for the development and maintenance of pregnancy.<\/jats:p>","DOI":"10.1590\/1806-9282.61.03.269","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:38:23Z","timestamp":1438205903000},"page":"269-274","source":"Crossref","is-referenced-by-count":33,"title":["Effects of melatonin and prolactin in reproduction: review of literature"],"prefix":"10.1590","volume":"61","author":[{"given":"Fernanda das Chagas Angelo Mendes","family":"Tenorio","sequence":"first","affiliation":[{"name":"Universidade Federal Rural de Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel de Jesus","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Wanderley","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Aguiar Coelho","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"186","article-title":"Mechanisms of disease","volume":"336","author":"Franklin H","year":"1997","journal-title":"N Engl J Med"},{"issue":"12","key":"ref2","first-page":"151","article-title":"Pineal melatonin: cell biology of its synthesis and of its physiological interactions","volume":"991","author":"Reiter RJ","journal-title":"Endoc Rev"},{"key":"ref3","first-page":"1","article-title":"Melatonin and pineal gland","volume":"2","author":"Hissa MN","year":"2008","journal-title":"Rev Elect Pesq M\u00e9d"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1210\/jcem-72-4-819","article-title":"Sequential cerebrospinal fluid and plasma sampling in humans: 24-hour melatonin measurements in normal subjects and after peripheral sympathectomy","volume":"72","author":"Bruce J","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1590\/S0004-27302000000400009","article-title":"Gl\u00e2ndula pineal e o metabolismo de carboidratos","volume":"44","author":"Seraphim PM","year":"2000","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref6","first-page":"459","article-title":"Mediator substances of the pineal neuronal network of mammals","volume":"5","author":"Debreceni K","year":"1997","journal-title":"Neurobiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1525-1373.2000.22502.x","article-title":"Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation","volume":"1","author":"Karbownik M","year":"2000","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.32635\/2176-9745.RBC.2005v51n1.1997","article-title":"Melatonina e c\u00e2ncer - revis\u00e3o da literatura","volume":"1","author":"Sousa JA","year":"2005","journal-title":"Rev Bras Cancerol"},{"key":"ref9","series-title":"Cronobiologia: princ\u00edpios e aplica\u00e7\u00f5es","first-page":"191","volume-title":"Gl\u00e2ndula pineal e melatonina","author":"Markus RP","year":"2003","edition":"3\u00aa"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s003810050177","article-title":"Experience with pineal region tumors","volume":"14","author":"Kang JK","year":"1998","journal-title":"Childs Nerv Syst"},{"key":"ref11","series-title":"Melatonin and the mammalian pineal gland","author":"Arend J","year":"1995"},{"key":"ref12","first-page":"217","article-title":"Melatonin and human reproduction","volume":"38","author":"Reiter RJ","year":"2005","journal-title":"J Pineal Res"},{"key":"ref13","first-page":"974","article-title":"Profile of organ weights and plasma concentrations of melatonin, estradiol and progesterone during gestation and postparturition periods in female indian palm squirrel Funambulus pennant Indian","volume":"38","author":"Bishnupuri KS","year":"2000","journal-title":"J Exp Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000184277","article-title":"Enhanced nocturnal melatonin secretion in women with functional secondary amenorrhea: relationship to opioid system and endogenous estrogen levels","volume":"43","author":"Okatani Y","year":"1995","journal-title":"Horm Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/jbc.M108890200","article-title":"Melatonin receptor activation regulates GnRH gene expression and secretion in GT1-7 GnRH neurons: signal transduction mech-anisms","volume":"277","author":"Roy D","year":"2002","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1034\/j.1600-079X.2002.02921.x","article-title":"Melatonin receptors in human fetal brain: 2-[125I] iodomelatonin binding sites and MT1 gene expression","volume":"33","author":"Thomas L","year":"2002","journal-title":"J Pineal Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/cne.21152","article-title":"Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone","volume":"499","author":"Wu YH","year":"2006","journal-title":"J Comp Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1695-4033(02)78685-2","article-title":"Pubertad y melatonina","volume":"57","author":"Murcia-Garc\u00eda J","year":"2002","journal-title":"J An Esp Pediatr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/0929867306666220330190146","article-title":"Melatonin","volume":"6","author":"Mor M","year":"1999","journal-title":"Curr Med Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1210\/jcem.86.10.7912","article-title":"Direct action of melatonin in human granulosa-luteal cells","volume":"86","author":"Woo MMM","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1016618405570","article-title":"Seasonal changes in human sperm chromatin condensation","volume":"18","author":"Henkel R","year":"2001","journal-title":"J Assist Reprod Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1196\/annals.1356.026","article-title":"Melatonin influences on the 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