{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:32:23Z","timestamp":1674891143167},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>SUMMARY Introduction: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. Methods: this is a retrospective cohort study of 27 patients aged 16 years or less with LBL admitted between January 1981 and December 2013. Patients received intensive chemotherapy regimen derived from acute lymphoblastic leukemia (ALL) therapy. Diagnosis was based on biopsy of tumor and\/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method. Results: the median age at diagnosis was 11.6 years (interquartile range, 4.6-13.8). LBL had T cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinum involvement in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with pB-LBL. Most patients had advanced disease (18 patients - 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4). Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.<\/jats:p>","DOI":"10.1590\/1806-9282.62.01.59","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T09:21:58Z","timestamp":1488532918000},"page":"59-64","source":"Crossref","is-referenced-by-count":2,"title":["Outcome of children and adolescents with lymphoblastic lymphoma"],"prefix":"10.1590","volume":"62","author":[{"given":"Maria Christina Lopes Ara\u00fajo","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyla Christy","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Carneiro","family":"Oliveira","sequence":"additional","affiliation":[{"name":"UFMG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aieska Dantas","family":"Santos","sequence":"additional","affiliation":[{"name":"UFMG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Porto","family":"Castro","sequence":"additional","affiliation":[{"name":"UFMG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Borato","family":"Viana","sequence":"additional","affiliation":[{"name":"UFMG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"20","key":"ref1","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1200\/JCO.2008.19.3367","article-title":"Poor outcome for children and adolescents with progressive disease or relapse of lymphoblastic lymphoma: a report from the Berlin-Frankfurt-Muenster Group","volume":"27","author":"Burkhardt B","year":"2009","journal-title":"J Clin Oncol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/pbc.20342","article-title":"Childhood and adolescent non-Hodgkin lymphoma: new insights in biology and critical challenges for the future","volume":"45","author":"Cairo MS","year":"2005","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3109\/08880018.2013.789574","article-title":"Lymphoblastic lymphoma in childhood and adolescence","volume":"30","author":"Schmidt E","year":"2013","journal-title":"Pediatr Hematol Oncol"},{"key":"ref4","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"168","volume-title":"B lymphoblastic leukaemia\/lymphoma, not otherwise specified","author":"Borowitz MJ","year":"2008"},{"key":"ref5","series-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","first-page":"176","volume-title":"T lymphoblastic leukaemia\/lymphoma","author":"Borowitz MJ","year":"2008"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1309\/Q5GV-3K00-WAC6-BBUB","article-title":"Precursor B-cell lymphoblastic lymphoma. 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