{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:31:49Z","timestamp":1766136709561},"reference-count":83,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Summary A retrospective study from November 2004 to May 2012, conducted at the Obstetric Clinic of Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo (HC-FMUSP), which included 92 singleton pregnancies with prenatal diagnosis of trisomy of chromosome 21 (T21), 18, 13 (T13\/18) and monosomy X (45X), with diagnosis performed until the 26th week of pregnancy. The aim of the study was to describe the frequency and to investigate predictors of spontaneous fetal death (FD). Diagnosis (T21, n=36; T13\/18, n=25; 45X, n=31) was made at a mean gestational age of 18.3\u00b13.7 weeks, through chorionic villus biopsy (n=22,24%), amniocentesis (n=66, 72%) and cordocentesis (n=4, 4%). Major malformations were present in 45 (49%); with hydrops in 32 (35%) fetuses, more frequently in 45X [n=24\/31, 77% vs. T21 (n=6\/36, 17%) and T13\/18 (n=2\/25, 8%), p&lt;0.001]. Specialized fetal echocardiography was performed in 60% (55\/92). Of these, 60% (33\/55) showed changes in heart morphology and\/or function. Fetuses with T13\/18 had a higher incidence of cardiac anomalies [60 vs. 25% (T21) and 29% (45X), p= 0.01]. FD occurred in 55 (60%) gestations, being more frequent in 45X [n=26\/31, 84% vs. T21 (n=13\/36, 36%) and T13\/18 (n=16\/25, 64%), p&lt;0.01]. Stepwise analysis showed a correlation between hydrops and death in fetuses with T21 (LR= 4.29; 95CI=1.9-8.0, p&lt;0.0001). In fetuses with 45X, the presence of echocardiographic abnormalities was associated with lower risk of FD (LR= 0.56; 95CI=0.27- 0.85, p=0.005). No predictive factors were identified in the T13\/18 group. Intra- uterine lethality of aneuploid fetuses is high. Occurrence of hydrops increases risk of FD in pregnancies with T21. In pregnancies with 45X, the occurrence of echocardiographic changes reduces this risk.<\/jats:p>","DOI":"10.1590\/1806-9282.62.02.162","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T19:31:30Z","timestamp":1462390290000},"page":"162-170","source":"Crossref","is-referenced-by-count":4,"title":["Intrauterine death in singleton pregnancies with trisomy 21, 18, 13 and monosomy X"],"prefix":"10.1590","volume":"62","author":[{"given":"Vanessa Vigna","family":"Goulart","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo Wenjaw","family":"Liao","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Henrique Burlacchini de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes","family":"Brizot","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana Pulcineli Vieira","family":"Francisco","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Zugaib","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1097\/01.AOG.0000291570.63450.44","article-title":"ACOG Practice Bulletin No. 88, December 2007. 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