{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:18:54Z","timestamp":1752229134113},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>SUMMARY Objective: To review the hypersensitivity reaction to drugs known as drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), based on a case report. We also intend to discuss the difficulty and importance of disease recognition, since none of the changes is pathognomonic of this disease and failure to identify it may have disastrous consequences for the patient. Method: To describe this case report, in addition to the information collected for clinical assessment, a literature review was performed in the PubMed and Bireme databases in order to retrieve the latest information published in literature on DRESS syndrome. Results: The case of a 20-year old patient is reported. After anamnesis, physical examination and laboratory tests a diagnosis of DRESS syndrome was performed, characterized by rash, hematologic alterations, lymphadenopathy and lesions in target organ. This is a rare syndrome, whose frequency varies according to the drug used and the immune status of the patient, being more often associated with the use of anticonvulsants. Conclusion: The approach and discussion of the topic are of paramount importance, in view of the potential lethality of this treatable syndrome. Recognizing the occurrence of DRESS syndrome and starting treatment as soon as possible is crucial to reduce the risk of mortality and improve prognosis.<\/jats:p>","DOI":"10.1590\/1806-9282.62.03.227","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T12:27:01Z","timestamp":1465648021000},"page":"227-230","source":"Crossref","is-referenced-by-count":7,"title":["Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)"],"prefix":"10.1590","volume":"62","author":[{"given":"Soraia Aparecida da","family":"Silva","sequence":"first","affiliation":[{"name":"Hospital Municipal Odilon Behrens, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Maciel Pereira de","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Barbacena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro","family":"Carneiro Neto","sequence":"additional","affiliation":[{"name":"Fame\/Funjob, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Borowiak","family":"Reiss","sequence":"additional","affiliation":[{"name":"Faculdade da Sa\u00fade e Ecologia Humana, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Amaranto de Souza","family":"Dam\u00e1sio","sequence":"additional","affiliation":[{"name":"Faculdade da Sa\u00fade e Ecologia Humana, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.02.2011.3898","article-title":"DRESS syndrome: a case report and literature review","volume":"2011","author":"Cardoso CS","year":"2011","journal-title":"BMJ Case Rep"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"693.e1","DOI":"10.1016\/j.jaad.2013.01.033","article-title":"DRESS syndrome: Part I. Clinical perspectives","volume":"68","author":"Husain Z","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: a literature review","volume":"124","author":"Cacoub P","year":"2011","journal-title":"Am J Med"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"709.e1","DOI":"10.1016\/j.jaad.2013.01.032","article-title":"DRESS syndrome: Part II. Management and therapeutics","volume":"68","author":"Husain Z","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"ref5","first-page":"435","article-title":"Rea\u00e7\u00e3o a drogas com eosinofilia e sintomas sist\u00eamicos (DRESS) \/ S\u00edndrome da hipersensibilidade induzida por drogas (DIHS): revis\u00e3o dos conceitos atuais","volume":"87","author":"Criado PR","year":"2012","journal-title":"An Bras Dermatol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaad.2012.08.009","article-title":"Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan","volume":"68","author":"Chen YC","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1684\/ejd.2010.0821","article-title":"Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro","volume":"20","author":"Mardivirin L","year":"2010","journal-title":"Eur J Dermatol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1525-1470.2011.01558.x","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with azithromycin in acute Epstein-Barr virus infection","volume":"28","author":"Bauer KA","year":"2011","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1085-5629(96)80038-1","article-title":"Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS)","volume":"15","author":"Bocquet H","year":"1996","journal-title":"Semin Cutan Med Surg"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/CCM.0b013e31821201ed","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome: a review","volume":"39","author":"Gerull R","year":"2011","journal-title":"Crit Care"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2141.2009.07599.x","article-title":"The hypereosinoplilic syndromes: current concepts and treatments","volume":"145","author":"Gleich GJ","year":"2009","journal-title":"Br J Haematol"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/CRD.0b013e31802ea93f","article-title":"Kawasaki disease: diagnosis, management, and long-term implications","volume":"15","author":"Satou GM","year":"2007","journal-title":"Cardiol Rev"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v62n3\/0104-4230-ramb-62-3-0227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T04:08:24Z","timestamp":1600747704000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302016000300227&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0104-42302016000300227"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.62.03.227","relation":{},"ISSN":["0104-4230"],"issn-type":[{"value":"0104-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}