{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:09:05Z","timestamp":1792789745131,"version":"4.5.0"},"reference-count":91,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>SUMMARY Objective: This review aims to update knowledge about Ebola virus disease (EVD) and recent advances in its diagnosis, treatment and prevention. Method: A literature review was performed using the following databases: ISI Web of Knowledge, PubMed, IRIS, Scopus and the websites of the CDC and the WHO. Additionally, we have included articles and reports referenced in the basic literature search, and news that were considered relevant. Results: The Ebola virus, endemic in some parts of Africa, is responsible for a severe form of hemorrhagic fever in humans; bats are probably its natural reservoir. It is an extremely virulent virus and easily transmitted by bodily fluids. EVD's complex pathophysiology, characterized by immunosuppression as well as stimulation of an intense inflammatory response, results in a syndrome similar to septic shock. The diagnosis is difficult due to the initial symptoms that mimic other diseases. Despite the high mortality rates that can amount to 90%, a prophylaxis (chemical or vaccine) or effective treatment does not exist. Two vaccines and experimental therapies are being developed for the prevention and treatment of EVD. Conclusion: Although the virus is known for about 40 years, the lack of knowledge obtained and the disinterest of government authorities in the countries involved justify the state of emergency currently exists regarding this infectious agent. Only the coordination of multiple entities and the effective commitment of the international community will facilitate the control and effective prevention of EVD.<\/jats:p>","DOI":"10.1590\/1806-9282.62.05.458","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T22:01:26Z","timestamp":1474149686000},"page":"458-467","source":"Crossref","is-referenced-by-count":2,"title":["Ebola virus \u2013 from neglected threat to global emergency state"],"prefix":"10.1590","volume":"62","author":[{"given":"Daniela Alexandra de Meneses Rocha Aguiar","family":"Pacheco","sequence":"first","affiliation":[{"name":", Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ac\u00e1cio Agostinho Gon\u00e7alves","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Maria Lisboa da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"9","key":"ref1","first-page":"442","article-title":"Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis","volume":"72","author":"Goeijenbier M","year":"2014","journal-title":"Neth J Med"},{"key":"ref2","series-title":"Haemorrhagic fevers, Viral","year":"2015"},{"issue":"2","key":"ref3","first-page":"271","article-title":"Ebola haemorrhagic fever in Zaire, 1976","volume":"56","year":"1978","journal-title":"Bull World Health Organ"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.micinf.2014.12.004","article-title":"Development of vaccines for prevention of Ebola virus infection","volume":"17","author":"Ye L","year":"2015","journal-title":"Microbes Infect"},{"key":"ref5","series-title":"Ebola virus disease","year":"2016"},{"key":"ref6","series-title":"WHO: Ebola \u2018an international emergency\u2019","year":"2014"},{"issue":"4","key":"ref7","first-page":"230","article-title":"[Ebola virus disease, an overview of the problem]","volume":"27","author":"Men\u00e9ndez JM","year":"2014","journal-title":"Rev Esp Quimioter"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jama.1997.03550050061035","article-title":"Clinical recognition and management of patients exposed to biological warfare agents","volume":"278","author":"Franz DR","year":"1997","journal-title":"JAMA"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3201\/eid0802.010164","article-title":"Public health assessment of potential biological terrorism agents","volume":"8","author":"Rotz LD","year":"2002","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.micinf.2014.11.012","article-title":"Development of therapeutics for treatment of Ebola virus infection","volume":"17","author":"Li H","year":"2015","journal-title":"Microbes Infect"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1517\/14712598.2012.685152","article-title":"Current ebola vaccines","volume":"12","author":"Hoenen T","year":"2012","journal-title":"Expert Opin Biol Ther"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/tmi.12454","article-title":"Ebola outbreak in rural West Africa: epidemiology, clinical features and outcomes","volume":"20","author":"Dallatomasina S","year":"2015","journal-title":"Trop Med Int Health"},{"key":"ref13","series-title":"Outbreaks chronology: Ebola virus disease","year":"2015"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/srep00811","article-title":"Transmission of Ebola virus from pigs to non-human primates","volume":"2","author":"Weingartl HM","year":"2012","journal-title":"Sci Rep"},{"issue":"2","key":"ref15","first-page":"247","article-title":"Ebola haemorrhagic fever in Sudan, 1976","volume":"56","year":"1978","journal-title":"Bull World Health Organ"},{"issue":"7-8","key":"ref16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.micinf.2005.04.006","article-title":"The natural history of Ebola virus in Africa","volume":"7","author":"Pourrut X","year":"2005","journal-title":"Microbes Infect"},{"issue":"2","key":"ref17","first-page":"451","article-title":"Ebola virus outbreaks in Africa: past and present","volume":"79","author":"Muyembe-Tamfum JJ","year":"2012","journal-title":"Onderstepoort J Vet Res"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/ijcp.12593","article-title":"What is Ebola?","volume":"69","author":"Stein RA","year":"2015","journal-title":"Int J Clin Pract"},{"issue":"6086","key":"ref19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/bmj.2.6086.541","article-title":"A case of Ebola virus infection","volume":"2","author":"Emond RT","year":"1977","journal-title":"Br Med J"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3201\/eid0911.030339","article-title":"Ebola hemorrhagic fever transmission and risk factors of contacts, Uganda","volume":"9","author":"Francesconi P","year":"2003","journal-title":"Emerg Infect Dis"},{"issue":"Suppl 3","key":"ref21","doi-asserted-by":"crossref","first-page":"S761","DOI":"10.1093\/infdis\/jir294","article-title":"Filovirus outbreak detection and surveillance: lessons from Bundibugyo","volume":"204","author":"MacNeil A","year":"2011","journal-title":"J Infect Dis"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0974-777X.145247","article-title":"The emergence of ebola as a global health security threat: from \u2018lessons learned\u2019 to coordinated multilateral containment efforts","volume":"6","author":"Kalra S","year":"2014","journal-title":"J Glob Infect Dis"},{"key":"ref23","series-title":"2014 Ebola Outbreak in West Africa - Case Counts","year":"2015"},{"issue":"6200","key":"ref24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.345.6200.989","article-title":"Genomes reveal start of Ebola outbreak","volume":"345","author":"Vogel G","year":"2014","journal-title":"Science"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.15252\/emmm.201404792","article-title":"Investigating the zoonotic origin of the West African Ebola epidemic","volume":"7","author":"Mar\u00ed Sa\u00e9z A","year":"2015","journal-title":"EMBO Mol Med"},{"key":"ref26","series-title":"Why Ebola is not likely to become airborne","year":"2015"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s40259-013-0046-1","article-title":"Emerging targets and novel approaches to Ebola virus prophylaxis and treatment","volume":"27","author":"Choi JH","year":"2013","journal-title":"BioDrugs"},{"issue":"Pt 9","key":"ref28","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1107\/S1399004714014710","article-title":"The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein","volume":"70","author":"Dziuba\u0144ska PJ","year":"2014","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"e00862","DOI":"10.1128\/mBio.00862-13","article-title":"Comprehensive functional analysis of N-linked glycans on Ebola virus GP1","volume":"5","author":"Lennemann NJ","year":"2014","journal-title":"mBio"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.4456","article-title":"Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses","volume":"235","author":"Martines RB","year":"2015","journal-title":"J Pathol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/v4123336","article-title":"Host cell factors in filovirus entry: novel players, new insights","volume":"4","author":"Hofmann-Winkler H","year":"2012","journal-title":"Viruses"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.coviro.2012.02.015","article-title":"Filovirus entry into cells - new insights","volume":"2","author":"Miller EH","year":"2012","journal-title":"Current Opin Virol"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/pro.688","article-title":"Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: stability and pH effects","volume":"20","author":"Harrison JS","year":"2011","journal-title":"Protein Sci"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.3390\/v6103837","article-title":"A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress","volume":"6","author":"Adu-Gyamfi E","year":"2014","journal-title":"Viruses"},{"issue":"16","key":"ref35","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1093\/emboj\/19.16.4228","article-title":"Crystal structure of the matrix protein VP40 from Ebola virus","volume":"19","author":"Dessen A","year":"2000","journal-title":"EMBO J"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2013.07.015","article-title":"Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle","volume":"154","author":"Bornholdt ZA","year":"2013","journal-title":"Cell"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1473-3099(04)01103-X","article-title":"Pathogenesis of filoviral haemorrhagic fevers","volume":"4","author":"Mahanty S","year":"2004","journal-title":"Lancet Infect Dis"},{"issue":"9768","key":"ref38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann H","year":"2011","journal-title":"Lancet"},{"key":"ref39","series-title":"Ebola virus disease information for clinicians in U.S. healthcare settings 2015"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.09.001","article-title":"Clinical features and pathobiology of ebolavirus infection","volume":"55","author":"Ansari AA","year":"2014","journal-title":"J Autoimmun"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/S0002-9440(10)63592-4","article-title":"Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells","volume":"163","author":"Geisbert TW","year":"2003","journal-title":"Am J Pathol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.phrp.2011.04.001","article-title":"Incubation period of ebola hemorrhagic virus subtype zaire","volume":"2","author":"Eichner M","year":"2011","journal-title":"Osong Public Hand Res Perspect"},{"key":"ref43","series-title":"Travel and transport risk assessment: Ebola. Interim guidance for public health authorities and the transport sector","year":"2014"},{"key":"ref44","first-page":"141","article-title":"Patients infected with high-hazard viruses: scientific basis for infection control","volume":"11","author":"Peters CJ","year":"1996","journal-title":"Arch Virol Suppl"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cll.2009.12.001","article-title":"Ebola and marburg hemorrhagic fever","volume":"30","author":"Hartman AL","year":"2010","journal-title":"Clin Lab Med"},{"issue":"Suppl 1","key":"ref46","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1086\/514308","article-title":"Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients","volume":"179","author":"Bwaka MA","year":"1999","journal-title":"J Infect Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"S810","DOI":"10.1093\/infdis\/jir299","article-title":"Basic clinical and laboratory features of filoviral hemorrhagic fever","volume":"204 Suppl 3","author":"Kortepeter MG","year":"2011","journal-title":"J Infect Dis"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3201\/eid1612.100627","article-title":"Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda","volume":"16","author":"MacNeil A","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref49","series-title":"Viral hemorrhagic fevers","year":"2013"},{"key":"ref50","series-title":"Case definition for Ebola virus disease (EVD)","year":"2014"},{"key":"ref51","series-title":"Epidemiologic risk factors to consider when evaluating a person for exposure to Ebola virus","year":"2014"},{"key":"ref52","series-title":"Ebola virus disease: diagnosis","year":"2015"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/JVI.78.8.4330-4341.2004","article-title":"Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome","volume":"78","author":"Towner JS","year":"2004","journal-title":"J Virol"},{"key":"ref54","series-title":"Containing Ebola: 7 next-gen rapid diagnostic tests","author":"Leonard S","year":"2015"},{"key":"ref55","series-title":"First antigen rapid test for Ebola through emergency assessment and eligible for procurement","year":"2015"},{"issue":"Suppl 1","key":"ref56","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1086\/514318","article-title":"Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epid\u00e9mies \u00e0 Kikwit","volume":"179","author":"Rowe AK","year":"1999","journal-title":"J Infect Dis"},{"key":"ref57","series-title":"Ebola virus disease: transmission","year":"2015"},{"key":"ref58","series-title":"What we know about transmission of the Ebola virus among humans","year":"2014"},{"issue":"Suppl 1","key":"ref59","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1086\/514321","article-title":"Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995","volume":"179","author":"Ksiazek TG","year":"1999","journal-title":"J Infect Dis"},{"issue":"19","key":"ref60","doi-asserted-by":"crossref","first-page":"10370","DOI":"10.1128\/JVI.78.19.10370-10377.2004","article-title":"Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels","volume":"78","author":"Sanchez A","year":"2004","journal-title":"J Virol"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/7422","article-title":"Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients","volume":"5","author":"Baize S","year":"1999","journal-title":"Nat Med"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.drudis.2014.12.010","article-title":"Small molecule inhibitors of ebola virus infection","volume":"20","author":"Picazo E","year":"2015","journal-title":"Drug Discov Today"},{"key":"ref63","series-title":"Ethical considerations for use of unregistered interventions for Ebola virus disease (EVD)","year":"2014"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/1060028014561227","article-title":"Potential and emerging treatment options for Ebola virus disease","volume":"49","author":"Bishop BM","year":"2015","journal-title":"The Ann Pharmacother"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.3390\/v4112806","article-title":"Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections","volume":"4","author":"Iversen PL","year":"2012","journal-title":"Viruses"},{"key":"ref66","series-title":"DARPA may have a way to stop Ebola in its tracks","author":"Till B","year":"2014"},{"issue":"7520","key":"ref67","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu X","year":"2014","journal-title":"Nature"},{"key":"ref68","article-title":"FDA allows second experimental drug to be tested in Ebola patients","volume":"349","author":"McCarthy M","year":"2014","journal-title":"BMJ"},{"key":"ref69","series-title":"New trial of TKM-Ebola treatment to start in Sierra Leone","year":"2015"},{"issue":"7496","key":"ref70","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren TK","year":"2014","journal-title":"Nature"},{"key":"ref71","series-title":"BioCryst announces study results for BCX4430 in a non-human primate model of Ebola virus infection","year":"2014"},{"key":"ref72","series-title":"A Phase 1 Study to evaluate the safety, tolerability and pharmacokinetics of BCX4430","year":"2014"},{"key":"ref73","series-title":"One year into the Ebola epidemic: a deadly, tenacious and unforgiving virus","year":"2015"},{"key":"ref74","series-title":"Chimerix\u2019s Brincidofovir has in vitro activity against Ebola","year":"2014"},{"key":"ref75","series-title":"Chimerix\u2019s Brincidofovir given To Dallas, Nebraska Ebola patients","author":"Kroll D","year":"2014"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.antiviral.2014.02.014","article-title":"Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model","volume":"105","author":"Oestereich L","year":"2014","journal-title":"Antiviral Res"},{"key":"ref77","series-title":"Chimerix Ebola drug Brincidofovir begins testing In Liberia","author":"Caulderwood K","year":"2015"},{"issue":"7532","key":"ref78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/517009a","article-title":"Ebola raises profile of blood-based therapy","volume":"517","author":"Butler D","year":"2015","journal-title":"Nature"},{"issue":"11","key":"ref79","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1128\/AAC.03442-14","article-title":"Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies","volume":"58","author":"Heald AE","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref80","series-title":"Ebola virus disease: prevention","year":"2015"},{"key":"ref81","series-title":"Fact Sheet: screening and monitoring travelers to prevent the spread of Ebola","year":"2015"},{"issue":"10","key":"ref82","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nm.3702","article-title":"Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge","volume":"20","author":"Stanley DA","year":"2014","journal-title":"Nat Med"},{"issue":"7","key":"ref83","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nm1258","article-title":"Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses","volume":"11","author":"Jones SM","year":"2005","journal-title":"Nat Med"},{"issue":"5","key":"ref84","article-title":"Mucosal immunization of cynomolgus macaques with the VSVDeltaG\/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses","volume":"4","author":"Qiu X","year":"2009","journal-title":"PLoS One"},{"key":"ref85","series-title":"Ebola vaccine efficacy trial ready to launch in Guinea","year":"2015"},{"key":"ref86","series-title":"Major milestone for GSK\/NIH candidate Ebola vaccine as first doses shipped to Liberia for use in phase III clinical trial","year":"2015"},{"key":"ref87","series-title":"Outbreak","author":"Petersen W","year":"1995"},{"key":"ref88","series-title":"MicroKillers- Ebola","author":"Sayenga K","year":"2005"},{"key":"ref89","series-title":"Ebola R&D: Landscape of clinical candidates and trials","year":"2015"},{"issue":"9996","key":"ref90","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(15)61117-5","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial","volume":"386","author":"Henao-Restrepo AM","year":"2015","journal-title":"The Lancet"},{"key":"ref91","series-title":"A new Ebola vaccine: the journay so far. Infographic","year":"2015"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v62n5\/0104-4230-ramb-62-5-0458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T18:00:38Z","timestamp":1568397638000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302016000500458&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0104-42302016000500458"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.62.05.458","relation":{},"ISSN":["0104-4230"],"issn-type":[{"value":"0104-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}