{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:51:58Z","timestamp":1768251118678,"version":"3.49.0"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Summary Objective: To analyze the frequency of extubation failure in premature infants using conventional mechanical ventilation (MV) after extubation in groups subjected to nasal intermittent positive pressure ventilation (nIPPV) and continuous positive airway pressure (nCPAP). Method: Seventy-two premature infants with respiratory failure were studied, with a gestational age (GA) \u2264 36 weeks and birth weight (BW) &gt; 750 g, who required tracheal intubation and mechanical ventilation. The study was controlled and randomized in order to ensure that the members of the groups used in the research were chosen at random. Randomization was performed at the time of extubation using sealed envelopes. Extubation failure was defined as the need for re-intubation and mechanical ventilation during the first 72 hours after extubation. Results: Among the 36 premature infants randomized to nIPPV, six (16.6%) presented extubation failure in comparison to 11 (30.5%) of the 36 premature infants randomized to nCPAP. There was no statistical difference between the two study groups regarding BW, GA, classification of the premature infant, and MV time. The main cause of extubation failure was the occurrence of apnea. Gastrointestinal and neurological complications did not occur in the premature infants participating in the study. Conclusion: We found that, despite the extubation failure of the group of premature infants submitted to nIPPV being numerically smaller than in premature infants submitted to nCPAP, there was no statistically significant difference between the two modes of ventilatory support after extubation.<\/jats:p>","DOI":"10.1590\/1806-9282.62.06.568","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T21:08:38Z","timestamp":1478725718000},"page":"568-574","source":"Crossref","is-referenced-by-count":16,"title":["Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation"],"prefix":"10.1590","volume":"62","author":[{"given":"Daniela Franco Rizzo","family":"Komatsu","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna Maria de Albuquerque","family":"Diniz","sequence":"additional","affiliation":[{"name":"FMUSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Archanjo","family":"Ferraro","sequence":"additional","affiliation":[{"name":"FMUSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Esther Jurvest Rivero","family":"Ceccon","sequence":"additional","affiliation":[{"name":"FMUSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Adolfo Costa","family":"Vaz","sequence":"additional","affiliation":[{"name":"FMUSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1542\/peds.107.4.638","article-title":"Randomized trial of nasal synchronized intermittent mandatory ventilation compared with continuous positive airway pressure after extubation of very low birth weight 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LA","year":"1978","journal-title":"J Pediatr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F23","DOI":"10.1136\/fn.88.1.F23","article-title":"Improved outcomes for very low birthweight infants: evidence from New Zealand national population based data","volume":"88","author":"Darlow BA","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1542\/peds.112.5.1031","article-title":"A randomised, controlled trial comparing two different continuous positive airway pressure systems for successful extubation of extremely low birth weight infants","volume":"112","author":"Stefanescu BM","year":"2003","journal-title":"Pediatrics"},{"issue":"3","key":"ref16","first-page":"406","article-title":"Increased risk of gastrointestinal perforation in neonates mechanically ventilated with either face mask or nasal prongs","volume":"76","author":"Garland 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pressure (NCPAP) in the prevention of extubation failure in pre-term < 1,500 grams","volume":"91","author":"Khorana M","year":"2008","journal-title":"J Med Assoc Thai"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"F32","DOI":"10.1136\/fn.86.1.F32","article-title":"Prediction of extubation failure in preterm infants","volume":"86","author":"Dimitrou G","year":"2002","journal-title":"Arch dis Child Fetal Neonatal Ed"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3109\/14767058.2013.846316","article-title":"Unsyncronized nasal intermitente positive pressure versus nasal continuous positive airway pressure in preterm infants after extubation","volume":"27","author":"Kahramaner Z","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2-3","key":"ref22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-3782(99)00046-8","article-title":"Comparing the effects of nasal synchronized intermittent 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