{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:39:49Z","timestamp":1790375989720,"version":"4.1.0"},"reference-count":75,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Summary Adult T-cell leukemia\/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Twenty million people are believed to be infected throughout the world, mostly in Japan, Africa, the Caribbean, and South America, particularly in Brazil and Peru. ATL affects about 5% of infected individuals and is classified in the following clinical forms: acute, lymphoma, primary cutaneous tumoral, chronic (favorable and unfavorable), and smoldering (leukemic and non-leukemic). Although it is considered an aggressive disease, there are cases with a long progression. We emphasize the importance of clinical classification as an indispensable element for evaluating prognosis and appropriate therapeutic approach. Since several cases have been published in Brazil and this disease is still poorly known, we decided to make a review paper for dissemination of clinical, hematological and pathological aspects, diagnosis, and therapy. The best way to reduce the occurrence of ATL would be halting the transmission of the virus through breastfeeding.<\/jats:p>","DOI":"10.1590\/1806-9282.62.07.691","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T21:31:52Z","timestamp":1480541512000},"page":"691-700","source":"Crossref","is-referenced-by-count":20,"title":["Adult T-cell leukemia\/lymphoma"],"prefix":"10.1590","volume":"62","author":[{"given":"Pedro Dantas","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Farre","sequence":"additional","affiliation":[{"name":"Fiocruz Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achil\u00e9a Lisboa","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, 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M","year":"1986","journal-title":"Lancet"},{"issue":"8727","key":"ref4","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0140-6736(90)92896-P","article-title":"Infective dermatitis of Jamaican children: a marker for HTLV-I infection","volume":"336","author":"LaGrenade L","year":"1990","journal-title":"Lancet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1473-3099(07)70081-6","article-title":"Human T-lymphotropic virus 1: recent knowledge about an ancient infection","volume":"7","author":"Verdonck K","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"9168","key":"ref6","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0140-6736(98)09460-4","article-title":"Human T-lymphotropic virus type I infection","volume":"353","author":"Manns A","year":"1999","journal-title":"Lancet"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1309\/2YGD1P0QCVCWBLDX","article-title":"Adult T-cell leukemia\/lymphoma in Bahia, Brazil: analysis of prognostic factors in a group of 70 patients","volume":"128","author":"Bittencourt AL","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/cid\/cis273","article-title":"Infective dermatitis associated with human T-cell lymphotropic virus type 1: evaluation of 42 cases observed in Bahia, Brazil","volume":"54","author":"de Oliveira Mde F","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1086\/524695","article-title":"Early sequential development of infective dermatitis, human T cell lymphotropic virus type 1-associated myelopathy, and adult T cell leukemia\/lymphoma","volume":"46","author":"Farre L","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref10","first-page":"100","article-title":"HTLV-I associated infective dermatitis may be an indolent HTLV-I associated lymphoma","volume":"4","author":"Gon\u00e7alves DU","year":"2000","journal-title":"Braz J Infect Dis"},{"issue":"8782-8783","key":"ref11","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/0140-6736(91)92413-V","article-title":"Childhood infective dermatitis evolving into adult T-cell leukaemia after 17 years","volume":"338","author":"Hanchard B","year":"1991","journal-title":"Lancet"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jcv.2012.10.010","article-title":"Double integration band of HTLV-1 in a young patient with infective dermatitis who developed an acute form of adult T-cell leukemia\/lymphoma","author":"Oliveira PD","year":"2013","journal-title":"J Clin Virol"},{"issue":"Suppl 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epidemiological evidence","volume":"3","author":"Iwanaga M","year":"2012","journal-title":"Front Microbiol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1309\/AJCPL52QGQPZWFHE","article-title":"Analysis of cutaneous lymphomas in a medical center in Bahia, Brazil","volume":"140","author":"Bittencourt AL","year":"2013","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/02841860701704732","article-title":"A case of adult T-cell leukemia\/lymphoma (ATL) with a survival of more than 13 years","volume":"47","author":"Bittencourt AL","year":"2008","journal-title":"Acta Oncol"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1590\/S0036-46652001000500009","article-title":"Adult T-cell leukemia\/lymphoma associated with HTLV-1 infection in a Brazilian adolescent","volume":"43","author":"do Valle AC","year":"2001","journal-title":"Rev Inst Med 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A case report","volume":"31","author":"Bittencourt AL","year":"2009","journal-title":"Am J Dermatopathol"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/0284186X.2010.534815","article-title":"Acute adult T-cell leukemia\/lymphoma (ATL) presenting with cutaneous purpuric lesions: a rare presentation","volume":"50","author":"Oliveira PD","year":"2010","journal-title":"Acta Oncol"},{"issue":"15","key":"ref43","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1182\/blood-2010-11-316794","article-title":"Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia\/lymphoma","volume":"117","author":"Sawada Y","year":"2011","journal-title":"Blood"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2141.1999.01323.x","article-title":"Diversity of leukaemic cell morphology in ATL correlates with prognostic factors, aberrant immunophenotype and defective HTLV-1 genotype","volume":"105","author":"Tsukasaki K","year":"1999","journal-title":"Br J Haematol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/cncr.10480","article-title":"Adult T-cell leukemia\/lymphoma: a cytopathologic, immunocytochemical, and flow cytometric study","volume":"96","author":"Dahmoush L","year":"2002","journal-title":"Cancer"},{"issue":"21","key":"ref46","first-page":"4862","article-title":"Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo","volume":"57","author":"Etoh K","year":"1997","journal-title":"Cancer Res"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2257.2005.00698.x","article-title":"Proviral status of HTLV-1 integrated into the host genomic DNA of adult T-cell leukemia cells","volume":"27","author":"Kamihira S","year":"2005","journal-title":"Clin Lab Haematol"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.pas.0000213325.79368.2c","article-title":"Adult T-cell lymphoma\/leukemia with angioimmunoblastic T-cell lymphomalike features: report of 11 cases","volume":"31","author":"Karube K","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/imj.12394","article-title":"Adult T-cell leukaemia\/lymphoma can mimic other lymphomas in a non-endemic \u00e1rea: dilemmas in diagnosis and treatment","volume":"44","author":"Huang CT","year":"2014","journal-title":"Intern Med J"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze R","year":"2005","journal-title":"Blood"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1365-4632.2010.04568.x","article-title":"Cutaneous manifestations associated with HTLV-1 infection","volume":"49","author":"Bittencourt AL","year":"2010","journal-title":"Int J Dermatol"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/sj.leu.2403965","article-title":"FOXP3, a selective marker for a subset of adult T-cell leukaemia\/lymphoma","volume":"19","author":"Roncador G","year":"2005","journal-title":"Leukemia"},{"issue":"4","key":"ref53","first-page":"283","article-title":"Clinicopathological aspects of HTLV- I positive and negative cutaneous T-cell lymphoma: a comparative study","volume":"7","author":"Bittencourt AL","year":"2000","journal-title":"Eur J Dermatol"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12185-014-1519-9","article-title":"Microenvironment of adult T-cell leukemia\/lymphoma-associated nodal lesions","volume":"99","author":"Ohshima K","year":"2014","journal-title":"Int J Hematol"},{"key":"ref55","series-title":"Portaria n. 54 de 18\/07\/2016 - Aprova o Protocolo de Uso da Zidovudina para Tratamento do Adulto com Leucemia\/Linfoma Associa\u00e7\u00e3o ao V\u00edrus HTLV-1","year":"2016"},{"issue":"27","key":"ref56","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2010.28.0669","article-title":"Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia\/lymphoma showing improved survival in the leukemic subtypes","volume":"28","author":"Bazarbachi A","year":"2010","journal-title":"J Clin Oncol"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2230.2011.04141.x","article-title":"Cutaneous type adult T-cell leukaemia\/lymphoma successfully treated with narrowband ultraviolet B phototherapy","volume":"37","author":"Kudo H","year":"2012","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1365-2133.1995.tb06933.x","article-title":"Satisfactory remission achieved by PUVA therapy in a case of crisis-type adult T-cell leukaemia\/lymphoma with generalized cutaneous leukaemic cell infiltration","volume":"133","author":"Takemori N","year":"1995","journal-title":"Br J Dermatol"},{"issue":"22","key":"ref59","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1182\/blood-2009-09-242347","article-title":"Long-term study of indolent adult T-cell leukemia-lymphoma","volume":"115","author":"Takasaki Y","year":"2010","journal-title":"Blood"},{"issue":"26","key":"ref60","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1056\/NEJM199506293322603","article-title":"Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine","volume":"332","author":"Gill PS","year":"1995","journal-title":"N Engl J Med"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-4690-11-19","article-title":"Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, Canada","volume":"11","author":"Barbeau B","year":"2014","journal-title":"Retrovirology"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3960\/jslrt.50.9","article-title":"Treatment of adult T-cell leukemia","volume":"50","author":"Uozumi K","year":"2010","journal-title":"J Clin Exp Hematopathol"},{"issue":"34","key":"ref63","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1200\/JCO.2007.11.9958","article-title":"VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801","volume":"25","author":"Tsukasaki K","year":"2007","journal-title":"J Clin Oncol"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3816\/CLM.2003.n.027","article-title":"Denileukin diftitox and hyper-CVAD in the treatment of human T-cell lymphotropic virus 1-associated acute T-cell leukemia\/lymphoma","volume":"4","author":"Di Venuti G","year":"2003","journal-title":"Clin Lymphoma"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/1097-0142(19900115)65:2<327::AID-CNCR2820650224>3.0.CO;2-W","article-title":"Central nervous system involvement in adult T-cell leukemia\/lymphoma","volume":"65","author":"Teshima T","year":"1990","journal-title":"Cancer"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0002-9343(93)90174-N","article-title":"Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma","volume":"94","author":"Hande KR","year":"1993","journal-title":"Am J Med"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.bmt.1701533","article-title":"Poor outcome of autologous stem cell transplantation for adult T cell leukemia\/lymphoma: a case report and review of the literature","volume":"23","author":"Tsukasaki K","year":"1999","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"ref68","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/cas.12617","article-title":"Recent advances in the treatment of adult T-cell leukemia-lymphomas","volume":"106","author":"Utsunomiya A","year":"2015","journal-title":"Cancer 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