{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:48:03Z","timestamp":1768567683298,"version":"3.49.0"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>SUMMARY Introduction Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature. Method A review in the Pubmed database was performed using the keywords \u201cfat grafting and scar\u201d, \u201cfat grafting and keloid scar\u201d and \u201cfat grafting and hypertrophic scar.\u201d Inclusion criteria were articles written in English and published in the last 10 years, resulting in 15 studies. Results These articles indicate that autologous fat grafting carried out at sites with pathological scars leads to a reduction of the fibrosis and pain, an increased range of movement in areas of scar contraction, an increase in their flexibility, resulting in a better quality of scars. Conclusion So far, evidences suggest that autologous fat grafting for the treatment of keloids and hypertrophic scars is associated with a better quality of scars, leading to esthetic and functional benefits. However, this review has limitations and these findings should be treated with reservations, since they mostly came from studies with low levels of evidence.<\/jats:p>","DOI":"10.1590\/1806-9282.62.09.862","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T04:06:23Z","timestamp":1482379583000},"page":"862-866","source":"Crossref","is-referenced-by-count":16,"title":["Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars"],"prefix":"10.1590","volume":"62","author":[{"given":"VIN\u00cdCIUS ZOLEZI DA","family":"SILVA","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTONIO","family":"ALBACETE NETO","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRAZIELLE DE SOUZA","family":"HOR\u00c1CIO","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUILHERME AUGUSTO MAGALH\u00c3ES DE","family":"ANDRADE","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEANDRO DEBS","family":"PROC\u00d3PIO","sequence":"additional","affiliation":[{"name":"Sociedade Brasileira de Cirurgia Pl\u00e1stica, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PEDRO SOLER","family":"COLTRO","sequence":"additional","affiliation":[{"name":"USP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAYME ADRIANO","family":"FARINA J\u00daNIOR","sequence":"additional","affiliation":[{"name":"USP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/SAP.0b013e31821ee386","article-title":"Autologous fat grafting for correction of unaesthetic scars","volume":"69","author":"Guisantes E","year":"2012","journal-title":"Ann Plast Surg"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00266-008-9122-1","article-title":"Fat injection in severe burn outcomes: a new perspective of scar remodeling and reduction","volume":"32","author":"Klinger M","year":"2008","journal-title":"Aesth Plast Surg"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cps.2014.12.009","article-title":"Fat grafting for treatment of burns, burn scars, and other difficult wounds","volume":"42","author":"Piccolo NS","year":"2015","journal-title":"Clin Plast Surg"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.bjps.2014.08.049","article-title":"Immediate fat grafting in primary cleft lip repair","volume":"67","author":"Balkin DM","year":"2014","journal-title":"J Plast Reconstr Aesth Surg"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/PRS.0b013e3182195826","article-title":"The level of evidence pyramid: indicating levels of evidence in plastic and reconstructive surgery articles","volume":"128","author":"Sullivan D","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bjps.2014.04.030","article-title":"Improvement of facial scar appearance and microcirculation by autologous lipofilling","volume":"67","author":"Pallua N","year":"2014","journal-title":"J Plast Reconstr Aesth Surg"},{"issue":"Suppl 6","key":"ref7","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1016\/j.injury.2014.10.036","article-title":"Autologous fat graft as treatment of post short stature surgical correction scars","volume":"45","author":"Maione L","year":"2014","journal-title":"Injury"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12282-014-0541-3","article-title":"Fat grafting in immediate breast reconstruction. Avoiding breast sequelae","volume":"23","author":"Molt\u00f3Garc\u00eda R","year":"2016","journal-title":"Breast Cancer"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00266-014-0311-9","article-title":"Autologous fat graft in postmastectomy pain syndrome following breast conservative surgery and radiotherapy","volume":"38","author":"Maione L","year":"2014","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1097\/SCS.0b013e318292c1a4","article-title":"Management of traqueostomy scar by autologous fat transplantation: a minimally invasive new approach","volume":"24","author":"Mazzola IC","year":"2013","journal-title":"J Craniofac Surg"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bjps.2011.08.046","article-title":"Fat grafting accelerates revascularisation and decreases fibrosis following thermal injury","volume":"65","author":"Sultan SM","year":"2012","journal-title":"J Plast Reconstr Aesth Surg"},{"issue":"Suppl 2","key":"ref12","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1097\/SAP.0000000000000462","article-title":"Alleviation of neuropathic scar pain using autologous fat grafting","volume":"74","author":"Huang SH","year":"2015","journal-title":"Ann Plast Surg"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"303e","DOI":"10.1097\/PRS.0000000000000066","article-title":"Degeneration, regeneration, and cicatrization after fat grafting: dynamics total tissue remodeling during the first 3 months","volume":"133","author":"Kato H","year":"2014","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"ref14","first-page":"217","article-title":"Fat grafting in facial burns sequelae","volume":"57","author":"Viard R","year":"2012","journal-title":"Ann Chir Plast Esthet"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/PRS.0b013e31821e70e7","article-title":"Autologous fat graft in postmastectomy pain syndrome","volume":"128","author":"Caviggioli F","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/SCS.0b013e31822e5d5e","article-title":"Structural fat grafting: facial volumetric restoration in complex reconstructive surgery","volume":"22","author":"Clauser LC","year":"2011","journal-title":"J Craniofac Surg"},{"issue":"3 Suppl","key":"ref17","doi-asserted-by":"crossref","first-page":"108S","DOI":"10.1097\/01.prs.0000234610.81672.e7","article-title":"Structural fat grafting: more than a permanent filler","volume":"118","author":"Coleman SR","year":"2006","journal-title":"Plast Reconstr Surg"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v62n9\/0104-4230-ramb-62-9-0862.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T04:46:27Z","timestamp":1601268387000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302016000900862&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0104-42302016000900862"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.62.09.862","relation":{},"ISSN":["0104-4230"],"issn-type":[{"value":"0104-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}