{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:30:38Z","timestamp":1783722638595,"version":"3.55.0"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Summary  Introduction: The purpose of this study was to evaluate the prevalence of peripheral polyneuropathy (PPN) in subjects with grade II and III obesity (Ob-II,III) and metabolic syndrome (MetS) but without diabetes and to investigate possible associated factors.  Method: A cross-sectional study was performed in non-diabetic Ob-II,III,MetS patients using the Michigan Neuropathy Screening Instrument (MNSI) to assess the presence of PPN.  Results: A total of 24 of 218 non-diabetic Ob-II,III,MetS patients had PPN. Based on univariate analysis, serum levels of LDL-cholesterol (p=0.046) were significantly associated with PPN, while serum triglycerides (p=0.118) and low HDL-cholesterol (p=0.057) showed a tendency toward this association. On a Poisson regression analysis, when the three possible associations were included, low HDL-cholesterol (p=0.047) remained independently associated.  Conclusion: In non-diabetic Ob-II,III,MetS patients, PPN defined by the MNSI showed a high prevalence and was associated with low levels of HDL-cholesterol. In order to diagnose that complication, neurological evaluation should be performed in these patients.<\/jats:p>","DOI":"10.1590\/1806-9282.63.04.324","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T23:15:06Z","timestamp":1497136506000},"page":"324-331","source":"Crossref","is-referenced-by-count":11,"title":["Peripheral polyneuropathy in severely obese patients with metabolic syndrome but without diabetes: Association with low HDL-cholesterol"],"prefix":"10.1590","volume":"63","author":[{"given":"Otto Henrique","family":"Nienov","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Matte","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisiane Stefani","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brazil; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Schmid","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brazil; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre,  Brazil; Hospital de Cl\u00ednica de Porto Alegre,  Brazil; Complexo Hospitalar Santa Casa de Miseric\u00f3rdia de Porto Alegre,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. 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