{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:29:13Z","timestamp":1790890153245,"version":"4.1.0"},"reference-count":49,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Summary Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting in a dilemma in cytopathological routine. Based on the difficulties of cytopathologic evaluation for the follow-up of patients treated with radiotherapy for cervical cancer, our objective was to describe the actinic cytopathic effects. Our paper was based on a structured review including the period from June 2015 to April 2016, aiming at an exploratory-descriptive study. Bibliographic investigations were carried out through selection and analysis of articles, list of authors and keywords, selection of new articles focused on the analysis of bibliographic references to previously selected documents, as well as textbooks of recognized merit. The most incident actinic cytopathological alterations as described in the literature are: cellular gigantism, nuclear and cytoplasmic vacuolization, dyskeratosis, bi- and multinucleated (B\/M) cells, macro and multiple nucleoli, anisokaryosis, anisonucleolosis and nuclear pyknosis. To date, a protocol has not been established that can precisely differentiate the morphological characteristics between benign cells with actinic effects from recurrent malignant cells on post-radiotherapy smears.<\/jats:p>","DOI":"10.1590\/1806-9282.63.04.379","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T23:15:37Z","timestamp":1497136537000},"page":"379-385","source":"Crossref","is-referenced-by-count":6,"title":["Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer"],"prefix":"10.1590","volume":"63","author":[{"given":"C\u00e1tia Martins Leite","family":"Padilha","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; Instituto Nacional de C\u00e2ncer, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio L\u00facio Cordeiro","family":"Ara\u00fajo Junior","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, Brazil; INCA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Augusto Lopes de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Radioterapia"},{"issue":"3","key":"ref2","first-page":"23","article-title":"Analysis of actinic effect after radiotherapy in the uterine cervix carcinomas","volume":"2","author":"Padilha CML","year":"2006","journal-title":"J Am Sci"},{"key":"ref3","series-title":"Estimativa 2016: Incid\u00eancia de C\u00e2ncer no Brasil \/ Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva. Coordena\u00e7\u00e3o de Preven\u00e7\u00e3o e Vigil\u00e2ncia","year":"2014"},{"issue":"3","key":"ref4","first-page":"517","article-title":"Women diagnosed with advanced cancer of the cervix: coping with the disease and treatment","volume":"58","author":"Panobianco MS","year":"2012","journal-title":"Rev Bras Cancerol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1748-717X-9-55","article-title":"A phase II study of concurrent chemo-radiotherapy with weekly nedaplatin in advanced squamous cell carcinoma of the uterine cervix","volume":"9","author":"Yuan G","year":"2014","journal-title":"Radiation Oncol"},{"issue":"16","key":"ref6","first-page":"2114","article-title":"Bethesda 2001 Workshop. The 2001 Bethesda System: terminology for reporting results of cervical cytology","volume":"287","author":"Solomon D","year":"2002","journal-title":"JAMA"},{"key":"ref7","series-title":"Nomenclatura Brasileira para Laudos Citopatol\u00f3gicos Cervicais. 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