{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:11:51Z","timestamp":1774055511336,"version":"3.50.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Summary Objective: To evaluate the effect of male factor infertility on intracytoplasmic sperm injection (ICSI) outcomes compared with a control group presenting isolated tubal factor. Method: This retrospective study included 743 couples undergoing ICSI as a result of isolated male factor and a control group consisting of 179 couples undergoing ICSI as a result of isolated tubal factor, performed in a private university- -affiliated in vitro fertilization center, between January\/2010 and December\/2016. Patients were divided into two groups according to maternal age: women \u226435 years old and &gt;35 years old. The effects of infertility causes on laboratorial and clinical ICSI outcomes were evaluated using Student's t-test and (2 test. Results: No differences in controlled ovarian stimulation outcomes were observed between male factor cycles and tubal factor cycles in the two age groups. Implantation (male factor 35.5% vs. tubal factor 32.0%, p=0.340), pregnancy (male factor 46.9% vs. tubal factor 40.9%, p=0.184) and miscarriage (male factor 10.3% vs. tubal factor 10.6%, p=0.572) rates were similar between the infertility groups, irrespective of female age. Considering maternal age, the cancelation rate was higher in older women (&gt;35 years old) undergoing ICSI as a result of male factor infertility (17.4% vs. 8.9%, p=0.013). Conclusion: Our results showed that there is no difference in the outcomes of pregnancy between couples with male or tubal factor infertility, which indicates that ICSI surpasses the worse specific outcomes associated with male factor.<\/jats:p>","DOI":"10.1590\/1806-9282.63.08.697","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T23:30:47Z","timestamp":1506814247000},"page":"697-703","source":"Crossref","is-referenced-by-count":4,"title":["Overcoming male factor infertility with intracytoplasmic sperm injection"],"prefix":"10.1590","volume":"63","author":[{"given":"Edson","family":"Borges Jr.","sequence":"first","affiliation":[{"name":"Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Ferrarini","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Paes de Almeida Ferreira","family":"Braga","sequence":"additional","affiliation":[{"name":"Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Souza","family":"Setti","sequence":"additional","affiliation":[{"name":"Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia S\u00e1vio","family":"Figueira","sequence":"additional","affiliation":[{"name":"Fertility Medical Group, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aguinaldo C\u00e9sar","family":"Nardi","sequence":"additional","affiliation":[{"name":"Fertility Medical Group, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assumpto","family":"Iaconelli Jr.","sequence":"additional","affiliation":[{"name":"Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.fertnstert.2009.10.030","article-title":"Sperm chromatin structure is associated with the quality of spermatogenesis in infertile patients","volume":"94","author":"Smit M","year":"2010","journal-title":"Fertil Steril"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/0970-1591.78426","article-title":"Guideline-based management of male infertility: Why do we need it?","volume":"27","author":"Trost LW","year":"2011","journal-title":"Indian J Urol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF03016134","article-title":"Sperm function and assisted reproduction technology","volume":"4","author":"Henkel R","year":"2005","journal-title":"Reprod Med Biol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen","volume":"16","author":"Cooper TG","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF01139210","article-title":"The limitations of in vitro fertilization from males with severe oligospermia and abnormal sperm morphology","volume":"1","author":"Yovich JL","year":"1984","journal-title":"J In Vitro Fert Embryo Transf"},{"issue":"8810","key":"ref6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo G","year":"1992","journal-title":"Lancet"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1093\/humrep\/deg403","article-title":"Pregnancy outcome and neonatal data of children born after ICSI using testicular sperm in obstructive and non-obstructive azoospermia","volume":"18","author":"Vernaeve V","year":"2003","journal-title":"Hum Reprod"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113671","article-title":"Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility","volume":"9","author":"Palermo GD","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2014.17985","article-title":"Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection","volume":"313","author":"Boulet SL","year":"2015","journal-title":"JAMA"},{"issue":"9274","key":"ref10","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0140-6736(00)05179-5","article-title":"Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial","volume":"357","author":"Bhattacharya S","year":"2001","journal-title":"Lancet"},{"key":"ref11","series-title":"2013Assisted Reproductive Technology Fertility Clinic Success Rates Report"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0015-0282(16)58257-0","article-title":"Intracytoplasmic sperm injection: a powerful tool to overcome fertilization failure","volume":"65","author":"Palermo GD","year":"1996","journal-title":"Fertil Steril"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/oxfordjournals.humrep.a138071","article-title":"Sperm\/egg binding patterns and oocyte cytology in retrospective analysis of fertilization failure in vitro","volume":"8","author":"Bedford JM","year":"1993","journal-title":"Hum Reprod"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/oxfordjournals.humrep.a137655","article-title":"Oocyte dysmorphism and aneuploidy in meiotically mature human oocytes after ovarian stimulation","volume":"7","author":"Van Blerkom J","year":"1992","journal-title":"Hum Reprod"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jemt.1070270209","article-title":"Cytogenetic, cellular, and developmental consequences of cryopreservation of immature and mature mouse and human oocytes","volume":"27","author":"Van Blerkom J","year":"1994","journal-title":"Microsc Res Tech"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/humrep\/deq231","article-title":"ESHRE PGD consortium best practice guidelines for amplification-based PGD","volume":"26","author":"Harton GL","year":"2011","journal-title":"Hum Reprod"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/aja.2011.65","article-title":"Male factor infertility and ART","volume":"14","author":"Tournaye H","year":"2012","journal-title":"Asian J Androl"},{"issue":"Suppl 1","key":"ref18","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1093\/humrep\/des200","article-title":"The oocyte","volume":"27","author":"Rienzi L","year":"2012","journal-title":"Hum Reprod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejogrb.2014.03.044","article-title":"Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?","volume":"178","author":"Kim JY","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.fertnstert.2012.08.026","article-title":"Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil Steril"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0015-0282(16)57913-8","article-title":"Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors","volume":"64","author":"Oehninger S","year":"1995","journal-title":"Fertil Steril"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2164\/jandrol.05156","article-title":"Semen and sperm reference ranges for men 45 years of age and older","volume":"27","author":"Hellstrom WJ","year":"2006","journal-title":"J Androl"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/humrep\/deg107","article-title":"The association of age and semen quality in healthy men","volume":"18","author":"Eskenazi B","year":"2003","journal-title":"Hum Reprod"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/oxfordjournals.humrep.a138192","article-title":"High fertilization and implantation rates after intracytoplasmic sperm injection","volume":"8","author":"Van Steirteghem AC","year":"1993","journal-title":"Hum Reprod"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1093\/oxfordjournals.humrep.a135801","article-title":"The role of intracytoplasmic sperm injection (ICSI) in the treatment of patients with borderline semen","volume":"10","author":"Aboulghar MA","year":"1995","journal-title":"Hum Reprod"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/humrep\/deg048","article-title":"Pregnancy course and health of children born after ICSI depending on parameters of male factor infertility","volume":"18","author":"Ludwig M","year":"2003","journal-title":"Hum Reprod"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4103\/1008-682X.146971","article-title":"ICSI treatment of severe male infertility can achieve prospective embryo quality compared with IVF of fertile donor sperm on sibling oocytes","volume":"17","author":"Zheng JF","year":"2015","journal-title":"Asian J Androl"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.fertnstert.2011.06.026","article-title":"National study of factors influencing assisted reproductive technology outcomes with male factor infertility","volume":"96","author":"Nangia AK","year":"2011","journal-title":"Fertil Steril"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.rbmo.2014.06.009","article-title":"Pregnancy outcome according to male diagnosis after ICSI with non-ejaculated sperm compared with ejaculated sperm controls","volume":"29","author":"Oldereid NB","year":"2014","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.fertnstert.2016.12.005","article-title":"Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection (IVF\/ICSI) treatments? Analysis of 100 prospectively recorded variables in 8,400 IVF\/ICSI single-embryo transfers","volume":"107","author":"Vaegter KK","year":"2017","journal-title":"Fertil Steril"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v63n8\/0104-4230-ramb-63-08-0697.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T23:37:31Z","timestamp":1750894651000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302017000800697&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0104-42302017000800697"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.63.08.697","relation":{},"ISSN":["0104-4230"],"issn-type":[{"value":"0104-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}