{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:41:49Z","timestamp":1784770909808,"version":"3.55.0"},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>Summary Currently Latin America is undergoing a major epidemic of Zika virus, which is transmitted by Aedes mosquitoes. Concern for Zika virus infection has been increasing as it is suspected of causing brain defects in newborns such as microcephaly and, more recently, potential neurological and autoimmune complications including Guillian-Barr\u00e9 syndrome and acute disseminated encephalomyelitis. We describe a case of virus infection in a 25-year-old woman during the first trimester of her pregnancy, confirmed by laboratory tests only for the detection of viral particles in maternal urine, with imaging studies demonstrating the progression of cranial and encephalic changes in the fetus and later in the newborn, such as head circumference reduction, cerebral calcifications and ventriculomegaly.<\/jats:p>","DOI":"10.1590\/1806-9282.64.01.11","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T15:17:26Z","timestamp":1521040646000},"page":"11-14","source":"Crossref","is-referenced-by-count":11,"title":["Microcephaly caused by congenital Zika virus infection and viral detection in maternal urine during pregnancy"],"prefix":"10.1590","volume":"64","author":[{"given":"Vanessa Couras","family":"Regadas","sequence":"first","affiliation":[{"name":"Documenta \u2013 Hospital Materno Infantil Sinh\u00e1 Junqueira,  Brazil; Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio de Castro e","family":"Silva","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital Materno Infantil Sinh\u00e1 Junqueira,  Brazil; Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Giansante","family":"Abud","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Mario Pereira Lopes","family":"Labadessa","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital Materno Infantil Sinh\u00e1 Junqueira,  Brazil; Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Gouv\u00eaa Gomes de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital Materno Infantil Sinh\u00e1 Junqueira,  Brazil; Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia Hissae","family":"Miyake","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-4422","authenticated-orcid":false,"given":"Rodolfo Mendes","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Documenta \u2013 Hospital Materno Infantil Sinh\u00e1 Junqueira,  Brazil; Documenta \u2013 Hospital S\u00e3o Francisco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,1]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00381-016-3074-6","article-title":"Microcephaly and Zika virus: neonatal neuroradiological aspects","volume":"32","author":"Cavalheiro S","year":"2016","journal-title":"Childs Nerv Syst"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s11255-016-1406-9","article-title":"Advantage of urine based molecular diagnosis of Zika virus","volume":"48","author":"Lamb LE","year":"2016","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/uog.17303","article-title":"Progressive lesions of central nervous system in microcephalic fetuses with suspected congenital Zika virus syndrome","volume":"50","author":"Sarno M","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"22","key":"ref4","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1056\/NEJMc1603617","article-title":"Computed tomographic findings in microcephaly associated with zika virus","volume":"374","author":"Hazin AN","year":"2016","journal-title":"Engl J Med"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar J","year":"2016","journal-title":"N Engl J Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/cid\/ciw613","article-title":"Fetal infection by zika virus in the third trimester: report of 2 cases","volume":"63","author":"Soares de Souza A","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/JCM.01232-16","article-title":"Zika virus testing considerations: lessons learned from the first 80 real-time reverse transcription-PCR-positive cases diagnosed in New York State","volume":"55","author":"St George K","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1148\/radiol.2016161584","article-title":"Congenital brain abnormalities and zika virus: what the radiologist can expect to see prenatally and postnatally","volume":"281","author":"Soares de Oliveira-Szejnfeld P","year":"2016","journal-title":"Radiology"},{"key":"ref9","series-title":"Lancet Infect Dis","first-page":"1356","volume-title":"Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study","volume":"16","author":"Ara\u00fajo TV","year":"2016"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v64n1\/0104-4230-ramb-64-01-0011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T15:04:06Z","timestamp":1522249446000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302018000100011&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["S0104-42302018000100011"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.64.01.11","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}